Agents commonly used in the treatment of neoplastic diseases may impair pulmonary function, and a wide spectrum of agents are currently implicated as toxic to the pulmonary system. Agents most commonly implicated are bleomycin, carmustine, busulfan, methotrexate, and thoracic radiotherapy. Less commonly implicated agents include mitomycin, procarbazine, melphalan, chlorambucil, and cyclophospha...

Despite recent insights into the pathobiology underlying central nervous system (CNS) malignant gliomas (MGs) and the development of new putative therapeutic compounds to treat these neoplasms, there remains no curative surgical or medical treatment for these tumors. Extensive surgical resection has been shown to prolong survival but is not a total cure because of widespread infiltrative micros...

The use of antineoplastic drugs in health care steadily increases. Health care workers can be occupationally exposed to antineoplastic drugs classified as carcinogenic or teratogenic. Monitoring of surface contamination is a common way to assess occupational exposure to antineoplastic drugs, since wipe sampling is used as a surrogate measure of dermal exposure. Since no occupational limits for ...

OBJECTIVES The objectives were (i) to identify occupational populations outside hospitals working with antineoplastic drugs, (ii) to determine the size of the populations 'at risk', (iii) to identify major determinants and routes of exposure outside hospitals and (iv) to estimate exposure levels and frequencies relative to levels found in hospitals. METHODS The survey consisted of two phases;...

There are two main mechanisms by which cells become multidrug resistant (MDR): by increasing drug efflux pumps on the cell membrane and by increasing anti-apoptotic pathways. The use of nanotechnology to develop nanodelivery systems has allowed researchers to overcome limitations of antineoplastic drugs by increasing the solubility of the drug and decreasing the toxicity to healthy tissues. By ...

Over 225 000 new cases of ovarian cancer are diagnosed each year. Symptoms are often vague, so most cases are detected when the disease is at an advanced stage. There is a need to find new drugs which will be able to treat ovarian cancer effectively. One of the most promising antineoplastic agents is trabectedin (Yondelis), derived from the marine tunicate Ecteinascidia turbinata, approved by t...

Nanotechnology is an emerging scientific field that allows manipulation of the environment at atomic and molecular level. The term cancer given to a group diseases whose main characteristic rapid multiplication abnormal cells. Conventional treatments used for are based mainly on use chemotherapy, radiotherapy, surgeries, nonspecific concerning target cells, because antineoplastic drugs can reac...

Nanoparticles have shown marked promise as both antineoplastic agents and drug carriers. Despite strides made in immunomodulation, low success rates toxicity remain limitations within the clinical oncology setting. In present review, we assess advances delivery nanoparticles, for systemic topical use, skin cancer treatment. A systematic review of controlled trials, meta-analyses, Cochrane artic...

There is some evidence for the antitumor effect of heparins, especially the low-molecular-weight ones. The authors discuss the potential mechanism of this antineoplastic effect and present results from several in vitro and in vivo experiments. The clinical trials concerning the impact of low-molecular-weight heparins on the tumor and on the patients' survival are described. The objective was to...

Both drug use and sex work considered as serious health and social problems. This study aimed to find the relation between them in young Iranian women. A mixed method of data collection applied from 300 young female sex workers in Tehran and 39 in-depth interviews with key informants. Result show that 84.4 % of participants used drugs before sex work. 46.2% of their fathers and 56.6% of their h...