نتایج جستجو برای: antimycobacterial agents
تعداد نتایج: 361721 فیلتر نتایج به سال:
Galactofuranose (Galf) is present in glycans critical for the virulence and viability of several pathogenic microbes, including Mycobacterium tuberculosis, yet the monosaccharide is absent from mammalian glycans. Uridine 5'-diphosphate-galactopyranose mutase (UGM) catalyzes the formation of UDP-Galf, which is required to produce Galf-containing glycoconjugates. Inhibitors of UGM have therefore ...
In 2022, we opened an outpatient clinic for the management of polypharmacy and potential drug–drug interactions (pDDIs) in patients with mycobacterial infection (called GAP-MyTB). All who underwent a GAP-MyTB visit from March 2022 to 2023 were included this retrospective analysis. Fifty-two database. They given 10.4 ± 3.7 drugs (2.8 1.0 7.8 3.9 were, respectively, antimycobacterial agents co-me...
A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...
Neither amoxicillin nor clavulanic acid used alone was active at the highest level tested, i.e., 256.0 micrograms/ml, in vitro against 24 isolates of Mycobacterium fortuitum, Mycobacterium kansasii, and Mycobacterium marinum. However, the MIC of an amoxicillin-clavulanic acid combination of 2:1 was < or = 8.0/4.0 micrograms/ml for 50 percent of the isolates tested, with all isolates being inhib...
BACKGROUND Biological agents such as tumor necrosis factor-α inhibitors are known to cause mycobacterium infections. Here, we report a disseminated non-tuberculosis case caused by TNF-α inhibitor therapy and a probable paradoxical response to antimycobacterial therapy. CASE PRESENTATION A 68-year-old man with relapsing polychondritis was refractory to glucocorticoid therapy; adalimumab was th...
TO THE EDITOR—The report on the intrinsic antimycobacterial activity of ibupro-fen and low-dose aspirin in a novel murine tuberculosis model is fascinating
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