The aim of the present study was to evaluate the impact of a multiple dose regimen of a liposomal formulation of meglumine antimoniate (LMA) on the pharmacokinetics of antimony in the bone marrow of dogs with visceral leishmaniasis and on the ability of LMA to eliminate parasites from this tissue. Dogs naturally infected with Leishmania chagasi received 4 intravenous doses of either LMA (6.5 mg...

The growing resistance of leishmaniasis to first-line drugs like antimonials in some regions limits the control of this parasitic disease. The precise mechanisms involved in Leishmania antimony resistance are still subject to debate. The reduction of intracellular SbIII accumulation is a common change observed in both laboratory-selected and field isolated resistant Leishmania strains, but the ...

The present paper proposes an analytical procedure for speciation analysis of inorganic antimony in airborne particulate matter using slurry sampling and hydride generation atomic absorption spectrometry (HG QT AAS). During the antimony determination, a quartz T tube cell was heated to approximately 900 C using air–acetylene flame. The optimization step was performed by employing full two-level...

A kinetic model for flame inhibition by antimony-halogen compounds in hydrocarbon flames is developed. Thermodynamic data for the relevant species are assembled from the literature, and calculations are performed for a large set of additional species of Sb-Br-C-H-O system. The main Sb- and Br-containing species in the combustion products and reaction zone are determined using flame equilibrium ...

Two new antimony telluride single source precursors (SSPs), Ph2SbTeR (R = Et, Ph), have been used to synthesise pure and defect free hexagonal Sb2Te3 nanoplates by thermal decomposition in an organic solvent. The chemical composition of the SSPs plays an important role in the formation of antimony telluride nanocrystals.

The reaction between 1,3,5-tris(4-hydroxyphenyl)benzene and benzene-1,3,5-tricarbonyl trichloride leads to polyester condensation and formation of a novel COF on an Au(111) surface. The characterization performed in situ by means of variable temperature STM and XPS reveals the formation of an array of hexagonal cavities with ca. 2 nm size.

Catalytic waves obtained from the perchloric acid-soluble fraction of serum in the presence of hexaminecobalt trichloride appear to conform to a Langmuir adsorption isotherm. Wave heights for sera from patients with untreated urological cancers significantly exceed those from normal subjects. In general, treatment with diethylstilbestrol decreased the wave height. Effects of some other chemothe...

Emergence of resistance to pentavalent antimonials has become a severe obstacle in the treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Mitogen-activated protein kinases (MAPKs) are well-known mediators of signal transduction of eukaryotes, regulating important processes, like proliferation, differentiation, stress response, and apoptosis. In Leishmania, MAPK1 has been shown...

A novel one-pot method was developed for the synthesis of the title compounds starting from 4-chloro-1-aryl-1-butanones 1, phosphorus trichloride and acetic acid. The end products 2 were obtained in 20-94% yield. The cyclization step under acidic conditions probably occurs as a result of anchimeric assistance of the phosphonic acid group.