نتایج جستجو برای: antimitotic agents
تعداد نتایج: 360808 فیلتر نتایج به سال:
Investigating the role of intrinsic cell heterogeneity emerging from variations in cell-cycle parameters and apoptosis is a crucial step toward better informing drug administration. Antimitotic agents, widely used in chemotherapy, target exclusively proliferative cells and commonly induce a prolonged mitotic arrest followed by cell death via apoptosis. In this paper, we developed a physiologica...
In our increasingly sophisticated world, it is remarkable how, even today, most decisions on combination chemotherapy regimens are still made on purely empirical grounds. Whereas several strategies have been pursued, the most common approach is to combine agents based on their single-agent activity and toxicity profile. Thus, if drug A has 20% activity in disease X as a single agent, and drug B...
Peloruside A is a novel antimitotic drug originally isolated from the marine sponge Mycale hentschieli. Previous studies showed that peloruside A stabilizes microtubules by binding to a site on tubulin distinct from paclitaxel, another microtubule stabilizing drug. Peloruside A blocks mitosis, but little is known about the effects on other cellular activities. Here we report that peloruside A i...
The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl a...
During cell division, cells form the microtubule-based mitotic spindle, a highly specialized and dynamic structure that mediates proper chromosome transmission to daughter cells. Cancer cells can show perturbed mitotic spindles and an approach in cancer treatment has been to trigger cell killing by targeting microtubule dynamics or spindle assembly. To identify and characterize proteins necessa...
Arabidopsis arenosa is a good candidate for phytoremediation due to its high tolerance Zn and Cd as well accumulation ability. However, small size low biomass are the largest obstacles applying it on broad scale. The aim was obtain polyploid specimens, which tend have higher increase translocation capacity of heavy metals in this metal-tolerant plant. Doubled polyploids (octaploids) were obtain...
A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues combretastatin A-4 (CA-4) were designed synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene bridge CA-4 was replaced with a β-lactam (2-azetidinone) scaffold. These compounds, together related prodrugs, evaluated for their antiproliferative acti...
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