نتایج جستجو برای: antimalarial plants

تعداد نتایج: 204162  

2015
Naazneen Khan Abdullah Chand

Considering malaria is a highly devastating disease of mankind, total eradication of malaria seems to be an uphill task, the only relief from this disease is achieved by usage of antimalarial drugs. Since malaria is associated with humans from time immemorial, usage of traditional substances to most presently effective antimalarial have been recorded to cure this disease. With the advent of mod...

Journal: :The Southeast Asian journal of tropical medicine and public health 2001
K Pattanapanyasat K Kotipun K Yongvanitchit R C Hider D E Kyle D G Heppner D S Walsh

Using standard in vitro drug susceptibility methods, we assessed the antimalarial activity of 3 orally administered iron chelators (hydroxypyridinones) alone and in combination with conventional antimalarials drugs (quinine, mefloquine, artesunate, tetracycline, atovaquone) against a chloroquine-resistant Plasmodium falciparum isolate. When tested alone, all iron chelators and antimalarial comp...

Journal: :Molecules 2010
Abdulelah H Al-Adhroey Zurainee M Nor Hesham M Al-Mekhlafi Rohela Mahmud

The methanolic extract of Languas galanga rhizomes was investigated for antimalarial activity against Plasmodium berghei (NK65) infections in mice. The median lethal dose was determined to ascertain the safety of the extract in ICR mice of both sexes. The antimalarial activities during early and established infections, as well as the prophylactic activity were evaluated. Phytochemical screening...

Journal: :Antimicrobial agents and chemotherapy 1995
J L Vennerstrom M T Makler C K Angerhofer J A Williams

In 1891 Guttmann and Ehrlich (P. Guttmann and P. Ehrlich, Berlin Klin. Wochenschr. 28:953-956, 1891) were the first to report the antimalarial properties of a synthetic, rather than a natural, material when they described the clinical cure of two patients after oral administration of a thiazine dye, methylene blue. Since that time, sporadic reports of the antimalarial properties of several xant...

2013
J. N. Boampong E. O. Ameyaw B. Aboagye K. Asare S. Kyei J. H. Donfack E. Woode

Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The anti...

2015
Shengyong Ng Robert E. Schwartz Sandra March Ani Galstian Nil Gural Jing Shan Mythili Prabhu Maria M. Mota Sangeeta N. Bhatia

Malaria eradication is a major goal in public health but is challenged by relapsing malaria species, expanding drug resistance, and the influence of host genetics on antimalarial drug efficacy. To overcome these hurdles, it is imperative to establish in vitro assays of liver-stage malaria for drug testing. Induced pluripotent stem cells (iPSC) potentially allow the assessment of donor-specific ...

Journal: :Experimental parasitology 2011
Jian Zhang Fu Sheng Huang Wen Yue Xu Ying Wang Tao Li Zhou Jian Hua Duan

The antimalarial drug nitroquine is not only an effective antimalarial drug, it is also able to induce the melanization of Plasmodium species. However, the molecular mechanisms of the recognition reaction induced by this drug remain unclear. Silencing of thioester-containing protein-1 (TEP1) significantly compromised the ability of Anopheles gambiae to melanize the Plasmodium, leading to invest...

Journal: :Journal of medicinal chemistry 2010
Yuxiang Dong Sergio Wittlin Kamaraj Sriraghavan Jacques Chollet Susan A Charman William N Charman Christian Scheurer Heinrich Urwyler Josefina Santo Tomas Christopher Snyder Darren J Creek Julia Morizzi Maria Koltun Hugues Matile Xiaofang Wang Maniyan Padmanilayam Yuanqing Tang Arnulf Dorn Reto Brun Jonathan L Vennerstrom

The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro. Weak base functional groups were not required for high antimalarial potency, but they were essential for high antimalarial efficacy in P. berghei-infected mice. Five new ozonides with antimalarial efficacy and ADME profiles sup...

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