Malaria is the major parasitic infection in many tropical and subtropical regions, leading to more than one million deaths (principally young African children) out of 400 million cases each year (WHO world health report 2000). More than half of the world's population live in areas where they remain at risk of malaria infection. During last years, the situation has worsened in many ways, mainly ...

Malaria is one of the most widespread and serious parasitic diseases worldwide. Currently available antimalarial drugs have side effects, and many strains of Plasmodia have developed resistance to such drugs. The present review examines the use of annexins and of natural peptides from snake venom as a new class of anti-malarial agents, with the key property of reducing inflammation. Severe case...

Most of the anticancer chemotherapeutic drugs that are broadly and successfully used today are DNA-damaging agents. Targeting of DNA has been proven to cause relatively potent and selective destruction of tumor cells. However, the clinical potential of DNA-damaging agents is limited by the adverse side effects and increased risk of secondary cancers that are consequences of the agents' genotoxi...

Phyllanthus amarus (PA) is a small herb indigenous to Amazon Basin .It is well known for its medicinal properties and widely used by oriental countries. It is reported to contain lignans,alkaloids,flavonoids,galloatnoids ,glycosides and alkaloids. It possesses antiviral, antiparasitic, antimalarial, antimicrobial, anticancerous, anti-diabetic and anti-Cholesterol agents. It acts on kidney stone...

There has been tremendous growth in field of herbal medicine as therapeutic agents. Dennettia tripetala, is known to possess ethnomedicinal properties and used for centuries the Ayurvedic system treatments various diseases. The present review provides detailed description on distribution, ethno-medicinal use, phyto-constituents, biological plant that justifies its use a potential agent manageme...

The pathway of hemoglobin degradation by erythrocytic stages of the human malarial parasite Plasmodium falciparum involves initial cleavages of globin chains, catalyzed by several endoproteases, followed by liberation of amino acids from the resulting peptides, probably by aminopeptidases. This pathway is considered a promising chemotherapeutic target, especially in view of the antimalarial syn...