Pharmacogenetic investigation seeks to identify genetic factors that contribute to interpatient and interdrug variation in responses to antihypertensive drug therapy. Classical studies have characterized single gene polymorphisms of drug metabolizing enzymes that are responsible for large interindividual differences in pharmacokinetic responses to several antihypertensive drugs. Progress is bei...

Background: Antihypertensive agents used during pregnancy may vary from institution to and depend on resource availability. Objective: This study aimed determine the profile of antihypertensive drugs in low-middle-income countries impact these maternal fetal outcomes. Materials Methods: is a retrospective hypertensive pregnant patients admitted emergency unit at tertiary referral Hospital Indon...

Hypertension is a leading cause of cardiovascular mortality, but only about half of patients on antihypertensive therapy achieve blood pressure control. Preeclampsia is defined as pregnancy-induced hypertension and proteinuria, and is associated with increased maternal and perinatal mortality and morbidity. Similarly, a large number of patients with preeclampsia are non-responsive to antihypert...