Professor Hewer. I will ask Dr. Apley, who looked after this child, to give us the finical history. i PrJohn Apley. Let me first tell you about the family of this little girl, an only ?hild, who died in hospital three days before her first birthday. The father is a man in ftls early thirties, who owns a shop. The mother is a kind and pleasant woman of some ^venty years of age. They live in a sm...

Ninety patients participated in a randomised, double blind, placebo controlled comparison of terfenadine with astemizole in the treatment of hay fever. They entered the trial as a cohort before the grass pollen season and recorded daily their symptoms of itching eyes, sneezing, running nose, and blocked nose on visual analogue scales in diary cards. Over the eight weeks of the trial astemizole ...

Bilastine is a new second generation H1-antihistamine recently approved for the symptomatic treatment of allergic rhinitis (AR) and chronic urticaria (CU). Bilastine epitomizes the evolution of research on antihistamines concerning both efficacy and safety. In AR treatment, a number of large controlled clinical trials documented its efficacy, as assessed by improvement of all nasal and ocular s...

To the Editor: Despite advancements in our understanding of pathomechanism alopecia areata (AA), optimal therapies and means to predict treatment responses remain elusive. Cases AA with improvement after topical diphenylcyclopropenone (DPCP) immunotherapy antihistamine have been reported.1 Hence, we investigated role adjuvant antihistamines combination a corticosteroid (TC) superficial cryother...

SUZANNE EDWARDS Statistical Methods for the Analysis of Adverse Experience Data from Clinical Trials of New Drugs (Under the direction of GARY G. KOCH) In premarketing clinical trials of new drugs, data are collected to evaluate both the efficacy and the safety of the new drug relative to the control (s) . One aspect of the safety evaluation is the ascertainment of adverse experiences (e.g., he...

Mucosal inflammation underlies many of the specific and interrelated factors that contribute to nasal congestion shea butter is used by local healers as a treatment for inflammatory conditions including congestion. The aim this study was evaluate effects extracts Shea on diagnosed patients with Nasal