نتایج جستجو برای: antigenic profiles
تعداد نتایج: 171991 فیلتر نتایج به سال:
UNLABELLED The efficacy of current influenza vaccines requires a close antigenic match between circulating and vaccine strains. As such, timely identification of emerging influenza virus antigenic variants is central to the success of influenza vaccination programs. Empirical methods to determine influenza virus antigenic properties are time-consuming and mid-throughput and require live viruses...
SUMMARY Antigenic cartography is a useful technique to visualize and minimize errors in immunological data by projecting antigens to 2D or 3D cartography. However, a 2D cartography may not be sufficient to capture the antigenic relationship from high-dimensional immunological data. AntigenMap 3D presents an online, interactive, and robust 3D antigenic cartography construction and visualization ...
Influenza viruses have been responsible for large losses of lives around the world and continue to present a great public health challenge. Antigenic characterization based on hemagglutination inhibition (HI) assay is one of the routine procedures for influenza vaccine strain selection. However, HI assay is only a crude experiment reflecting the antigenic correlations among testing antigens (vi...
Influenza A virus continues to pose a threat to public health. Since this virus can evolve escape mutants rapidly, it is desirable to predict the antigenic evolution for developing effective vaccines. Although empirical methods have been proposed and reported to predict the antigenic evolution more or less accurately, they did not provide much insight into the effects of unobserved mutations an...
In this study 253 serum samples from cattle showing respiratory disorders were tested by confirmatory Western Immunoblotting test (IBT), complement fixation (CFT) and competitive enzyme linked immunosorbent assay (c-ELISA). Two (0.8%) out of found to be positive two doubtful CFT while 7 (2.8%) as 25 (9.9%) them c-ELISA. On the other hand, a core profile antigenic bands needed identified at 110,...
UNLABELLED Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are genetically highly variable and have diversified into multiple phylogenetic clades over the past decade. Antigenic drift is a well-studied phenomenon for seasonal human influenza viruses, but much less is known about the antigenic evolution of HPAI H5N1 viruses that circulate in poultry. In this study, we focuse...
Typically, human noroviruses cause symptoms of acute gastroenteritis for 2 to 4 days. Often, the virions are shed in stool for several days after the symptoms recede, which in turn can lead to further contamination and transmission. Moreover, a number of reports have considered that chronic norovirus infections, i.e., lasting months and years, might even function as reservoirs for the generatio...
1. Protein-polysaccharides isolated from bovine, human, and porcine cartilage are antigenic in the rabbit. 2. PP-L from each of these species contains a minimum of two antigenic determinants; one is species specific, and one is common to all three species. Human PP-H also contains these two determinants. 3. Both antigenic determinants are in, or closely associated with, the protein moiety of th...
Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza strains. To understand this phenomenon, we computed the Significant Interactions Network (SIN) for each residue and mapped the networks of antigenic site residues on a representa...
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