Tumilowicz, Joseph J. (Children's Hospital of Philadelphia, Philadelphia, Pa.), and Klaus Hummeler. Heterogeneity of apparently complete poliovirus particles. J. Bacteriol. 87:1105-1113. 1964.-A chromatographic procedure was developed for separating the N from the H complement-fixing antigen of poliovirus. This procedure concomitantly effected some separation of classes of N particle. The ratio...

KIF22, also known as kinesin-like DNA-binding protein (Kid), is a member of the Kinesin superfamily proteins (KIFs). Available evidence indicated that KIF22 was associated with cancer occurrence and development. However, functions underlying mechanisms in carcinogenesis progression remain largely unknown. In this study, we examined expression profile methylation status different cancers, well i...

one of the leading causes of death in the world are cardiovascular diseases, among which coronary artery disease (cad) is the most common one. it occurs as a result of narrowing of the arteries which supply blood to the heart due to a theroma plaque formation. this kind of heart disease can be considered as a multifactorial one as genetic and environmental factors are involved in its incidence....

Plasmacytoid dendritic cells (PDCs) are a unique leukocyte population capable of secreting high levels of type I interferon (IFN) in response to viruses and bacterial stimuli. In vitro experiments have shown that upon maturation, human and murine PDCs develop into potent immunostimulatory cells; however, their ability to prime an immune response in vivo remains to be addressed. We report that C...

T lymphocytes mediate many immunologic functions . For example, they generate cytotoxic responses to alloantigens (l, 2), exert helper (3) and suppressor (4) effects on the production of antibody, and initiate graft-vs.-host responses (5) . We do not know whether this diversity of function reflects a functional heterogeneity of T lymphocytes existing before antigen stimulation. If this were the...

ABO hemolytic disease of the newborn poses certain prognostic problems because maternal antibody titer is poorly related to severity of the ensuing hemolytic process. Heterogeneity of anti-A antibodies, as recently discussed by Polley e t al. [lo], may be one of the factors responsible for this poor association, Another factor may be the quantitative behavior of the A antigen. Infants with ABO ...

In vitro colony-forming ability of untreated acute nonlymphocytic leukemia (ANLL) cells determined by the CFU-C assay with and without PHA presensitization, and also human Ia-like antigen of their surfaces were investigated. In vitro colony-forming ability of 32 ANLLs was classified into four types: (A) no colony growth: 16, (B) PHA-dependent colony growth: 9, (C) colony-stimulating factor (CSF...

The existence of at least three alleles of the HLA-DRB3 gene within the human population is evident. These alleles express DRw52 determinants and react with monoclonal antibody (mAb) 7.3.19.1. The polymorphic epitope recognized by 7.3.19.1 is not only present on human cells but is also expressed on chimpanzee (Pan troglodytes) class II-positive cells. The 7.3.19.1 determinant already existed be...

Severe immunosuppression is an established risk factor for non-Hodgkin lymphoma (NHL), but an association with subclinical immune dysfunction is unclear. We conducted a case-control study nested in the Physicians' Health Study and the Nurses' Health Study cohorts to determine whether patterns of antibody response to Epstein-Barr virus (EBV) were associated with NHL risk. We measured antibody ti...

Monoclonal antibodies (MoAbs) 225.28, 657.9, and 902.5 recognizing distinct epitopes of the human high molecular weight melanoma associated antigen (HMW-MAA) were used to investigate the molecular and cellular heterogeneity of the HMW-MAA synthesized by human melanoma cells. Sequential immunodepletion and immunoprecipitation experiments showed that not all HMW-MAA molecules synthesized by a mel...