We have identified an agent (SP-303) that shows efficacy against in vivo cholera toxin-induced fluid secretion and in vitro cAMP-mediated Cl-secretion. Administration of cholera toxin to adult mice results in an increase in fluid accumulation (FA) in the small intestine (FA ratio = 0.63 vs. 1.86 in control vs. cholera toxin-treated animals, respectively). This elevation in FA induced by cholera...

India possess a rich biodiversity of the medicinal plants that were still not explored completely. The need for the novel pharmaceutical products out from the plant has attained a great interest in the present research world due to the cost and the higher side effects that are associated with the chemically manufactured drugs. Catharanthus roseus,which is a potent medicinal plant many of the ph...

The participation of renal metallothionein (Ml) in the toxicity and antitumor activity of cii-diamminedichloroplatinum(II) (cw-DDP) in male mice was examined. Preinduction of MT in the kidney by the s.c. administration of bismuth compounds decreased the lethality and renal and gastrointestinal toxicity caused by a single s.c. injection of c/j-DDP. In the present study a correlation between the ...

BACKGROUND: Bacterial gastroenteritis is a disease in the tropics form of inflammation stomach and intestines due to several bacteria, such as Salmonella, Campylobacter, Shigella, Escherichia coli, Vibrio, Yersinia, Listeria with symptoms diarrhea without or vomiting frequent fever. Gastroenteritis global highest prevalence agricultural community, especially farmers fishermen. AIM: This researc...