OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose. DESIGN Cohort study of people aged 65 and over diagnosed as having depression. SETTING 570 general practices in the United Kingdom supplying data to the QResearch ...

Background: Late-life depression (LLD) is one of the most common psychiatric disorders. However, LLD often undetected or inadequately treated by clinicians. This review summarizes recent research on pharmacotherapy for LLD, updates information monotherapy using recommended antidepressants, and discusses clinical features diagnostic criteria LLD.Current Concepts: The in both elderly young adults...

One theory concerning the action of antidepressants relates to the drugs’ ability to induce an adaptive plasticity in neurons such as neurite sprouting. Certain antidepressants are known to bind to -1 receptors (Sig-1R) with high affinity. Sig-1R are dynamic endoplasmic reticulum proteins that are highly concentrated at the tip of growth cones in cultured cells. We therefore tested the hypothes...

OBJECTIVES Antidepressants are commonly used in dementia. Depression is a frequent and important co-morbidity in dementia, and antidepressants are often used to treat depression and more widely. However, there are questions about their utility in depression in dementia and other behavioural and psychological symptoms of dementia. The aim of this narrative review is to summarize the evidence on ...

Introduction Evidence on neonatal withdrawal syndrome following antidepressant intrauterine exposure is limited, particularly for antidepressants other than selective serotonin reuptake inhibitors (SSRIs). Objectives To ascertain whether maternal treatment may be associated with in neonates, investigating the comparative reporting between individual and classes. Methods We performed a case/non-...

INTRODUCTION Several small studies have reported inconsistent findings about the safety of selective serotonin reuptake inhibitors (SSRIs) among patients undergoing coronary artery bypass grafting (CABG). We sought to investigate post-CABG bleeding and mortality outcomes related to antidepressant exposure. METHODS We identified patients who underwent CABG between 2004 and 2008 in the Premier ...