Introduction: Depression is a widely prevalent form of mental illnesses worldwide. It commonly associated with sad mood, loss interest or pleasure, feelings guilt low self-worth, disturbed sleep appetite, and energy. Mimosa pudica has many medicinal properties, are used in traditional medicine the treatment various medical conditions. This study was conducted to better understand antidepressant...

Although rarely reported, the induction of hypomanic/manic episodes due to sudden or gradual cessation of antidepressant drugs is a phenomenon observed in clinical settings. Herein we present 2 patients that had manic episodes induced by gradual cessation of antidepressant drugs. Common features of both cases were as follows: patients were female; a major depressive episode was the reason for s...

The aim of the study was to evaluate the in vivo and in vitro effects of antidepressant drugs on cytotoxic activity of rat spleen macrophages. In the in vivo experiment, rats were injected subcutaneously with two different doses (2 or 10 mg/kg) of desipramine, fluvoxamine and fluoxetine. The drugs were given once, for 2, 4 or 8 weeks. In the in vitro experiment, spleen macrophages were cultured...

Depressive disorders increase the risks of self-harm or even suicide in patients. Indigenous drugs are being tried to treat such patient along with conventional antidepressant drugs. This study was planned to investigate the antidepressant action of Ashwagandha and Bramhi and also to confirm its efficacy in the behavioural despair animal model of depression. Normal saline as control (5 ml/kg), ...

Although there is evidence for an important role of UGT2B10 in the N-glucuronidation of drugs and other xenobiotics, the inhibitor selectivity of this enzyme is poorly understood. This study sought primarily to characterize the inhibition selectivity of UGT2B10 by UDP-glucuronosyltransferase (UGT) enzyme-selective inhibitors used for reaction phenotyping, and 34 antidepressant and antipsychotic...

The aim of the study was to evaluate the in vivo and in vitro effects of antidepressant drugs on cytotoxic activity of rat spleen macrophages. In the in vivo experiment, rats were injected subcutaneously with two different doses (2 or 10 mg/kg) of desipramine, fluvoxamine and fluoxetine. The drugs were given once, for 2, 4 or 8 weeks. In the in vitro experiment, spleen macrophages were cultured...

OBJECTIVES The aim of this retrospective study was an analysis of antidepressant-induced mood conversions to mania/hypomania occurring in bipolar inpatients treated with antidepressants in the Affective Disorder Unit of the Institute of Psychiatry and Neurology, Warsaw, in the years 1972-1996. METHODS The data for analysis were obtained retrospectively from clinical records. In a subgroup of ...

Background: Poisoning is a serious health problem in the world. In the intentional type, the person may attempt suicide by self-poisoning or may be poisoned by others in a criminal act. The present study was designed to investigate the causes and the frequency of poisoning cases referring to Loqman Hospital, Tehran, Iran, during summer 2010. Methods: In this descriptive-analytical study, age...

It has been postulated that hyperactive glycogen synthase kinase-3 (GSK-3) is an important factor in the pathogenesis of depression, and that this enzyme also contributes to the mechanism of antidepressant drug action. In the present study, we investigated the effect of prenatal stress (an animal model of depression) and long-term treatment with antidepressant drugs on the concentration of GSK-...

Recently, prescribing of antidepressant drugs has increased exceptionally. At the same time, concerns have been raised about the medicalisation of human distress and, more recently, about the safety of antidepressants. Many general practitioners would like to refer patients for psychological treatment, for which there is good evidence of effectiveness, but are constrained by the lack of NHS the...