Antibody drugs play a critical role in infectious diseases, cancer, autoimmune diseases, and inflammation. However, experimental methods for the generation of therapeutic antibodies such as using immunized mice or directed evolution remain time consuming and cannot target a specific antigen epitope. Here, we describe the application of a computational framework called OptMAVEn combined with mol...

Dear Sir, Diagnosis and management of anti-Coltona (Coa) alloimmunisation during pregnancy is a rare and challenging condition. Only five cases have been described up to now, four in the 1970s and one in 2008, but diagnosis and management have changed in the meantime (Smith et al., 1970; Simpson, 1973; McIntyre et al., 1976; Fuhrmann et al., 1979; Michalewska et al., 2008). We here present such...

BACKGROUND Septic shock is a common and often devastating syndrome marked by severe cardiovascular dysfunction commonly managed with vasopressors. Whether markers of heart rate complexity before vasopressor up-titration could be used to predict success of the up-titration is not known. METHODS We studied patients with septic shock requiring vasopressor, newly admitted to the intensive care un...

Objective: Garlic is a plant has been used as a flavor, and anti-microbial and anti-diarrheal agent. Infectious bronchitis virus (IBV) is a coronavirus. The available vaccines against IBV cannot cover new variants. This study evaluated the inhibitory effects of garlic extract on IBV.  Materials and Methods: The constituents of garlic extract were detected by gas chromatography. This study was d...