The regulation of megakaryocytopoiesis and thrombopoiesis appears to be under the control of an array of hematopoietic growth factors. To determine the relationship of endogenous thrombopoietic cytokine levels and circulating platelet (PLT) counts, we measured the levels of thrombo-poietin (TPO), interleukin-11 (IL-11), and interleukin-6 (IL-6) in patients with significant thrombocytopenia seco...

Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal disease in humans and farm animals. E. coli fimbriae, or colonization factor antigens (CFAs), and enterotoxins, including heat-labile enterotoxins (LT) and heat-stable enterotoxins (ST), are the key virulence factors in ETEC diarrhea. Unlike fimbriae or LT, STa has not often been included as an antigen in development...

BACKGROUND During haemodialysis (HD) treatment, increase of platelet (PLT) activation and induction of procoagulant activity is demonstrated. Although the role of the endothelium and its direct interaction with coagulation and homeostasis is known, it is not elucidated how PLT activation markers and activation of coagulation coincide with markers of endothelial integrity during HD treatment. In...

BACKGROUND Blood loss after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass. Desmopressin or 1-deamino-8-D-arginine vasopressin (DDAVP) is a synthetic analog of vasopressin. DDAVP can increase the level of von Willebrand factor and coagulation factor VIII, thus it may enhance PLT function and improve coagulation. In this study, we assessed the effe...

BACKGROUND Buffy coat (BC) production of platelets (PLTs) has been successfully used in Europe for more than two decades. Currently, Canadian Blood Services is implementing the BC method. This article summarizes results of the validation testing performed to qualify the process of PLT production from whole blood and compares the quality of PLTs produced in routine production by either the PLT-r...

PURPOSE Necrotizing soft tissue infection is the infection of the soft tissue with necrotic changes. It is rare, but results in high mortality. We analyzed the characteristics of patients, prognosis, and mortality factors after reviewing 30 cases of a single hospital for 5 years. METHODS From January 2009 to December 2013, 30 patients diagnosed with necrotizing fasciitis or Fournier's gangren...

Dear Editor The recently launched hematology autoanalyzer Sysmex XN2000 (Sysmex, Kobe, Japan) provides a new method (PLT-F method) for platelet counting based on a fluorescent RNA staining dye named oxazine [1, 2]. The main advantage of the XN2000’s PLT-F method over the former instrument XE-2100’s optical method (PLT-O method) is the ability to identify apoptotic white cells and not count them...

Introduction: Automated hematology analyzer platelet counts can be performed using either the impedance (PLT-I) method or fluorescent nucleic acid staining (PLT-O) method. Estimated (PLT-E) calculated a digital morphology by evaluating peripheral blood smear. Our objective was to compare values detected on Mindray BC-6200 device PLT-E count MC-80 analyzer. Material and methods: Complete cell fi...