In recent years, the availability and use of various antibiotics and antimicrobial agents have resulted in increase of drug resistant pathogens. Therefore, scientist’s attention has been diverted to find a suitable replacement for antimicrobial treatment. Graphene (G), as a two-dimensional (2D) carbon-based nanomaterials (CBNs) has a unique physicochemical properties including thermal, optical ...

OBJECTIVE The aim of this study was to investigate the stability of fortified cefazolin sodium ophthalmic solutions (50 mg mL⁻¹) extemporaneously prepared in commercial artificial tears containing 2 different types of preservatives, namely the surfactants and oxidants. METHODS Fortified cefazolin sodium solutions were prepared by reconstituting cefazolin for injection with sterile water and f...

During the post-antibiotic golden age, it has seen a massive antibiotic/antibacterial production and an increase in irrational use of these few existing drugs in the medical and veterinary practice, food industries, tissue cultures, agriculture and commercial ethanol production globally. The irrational drug use has been further exacerbated by the increased marketing and promotion of these drugs...

OBJECTIVE Quinolone resistance is usually caused by various chromosomal mutations, but has been more recently associated with plasmids which carry the qnr determinant. The aim of this study is to investigate the prevalence of qnr genes in clinical isolates of Enterobacteriaceae in Jamaica. METHODS A total of 255 non-duplicate fluoroquinolone-resistant Enterobacteriaceae clinical isolates, com...

WCK 771 demonstrated MIC(50) and MIC(90)s of 0.03 and 1 microg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC(90)s of WCK 771 and moxifloxacin were 1 and 16 microg/ml, respectively.

silver sulfadiazine is used to prevent and treat infections of second- and third-degree burns. it kills a wide variety of bacteria. in this study silver sulfadiazine was used in gelatin based electro-spun nano-fibers with various drug to polymer ratios (0, 5, 10, 15 and 20 %). sem, edx and ftir analysis showed that the continuous, bead-free, fine fibers containing silver sulfadiazine as an anti...

Infections caused by drug-resistant microorganisms result in significant increases in mortality, morbidity, and cost related to prolonged treatments. The antibacterial activity of silver nanoparticles against some drug-resistant bacteria has been established, but further investigation is needed to determine whether these particles could be an option for the treatment and prevention of drugresis...

Silver nanoparticles (AgNPs) are ultra-small silver particles with a size from 1 to 100 nanometers. Unlike bulk silver, they have unique physical and chemical properties. Numerous studies shown that AgNPs beneficial biological effects on various diseases, including antibacterial, anti-inflammatory, antioxidant, antiparasitic, antiviruses. One of the most well-known applications is in field anti...

BACKGROUND The discovery of new solutions with antibacterial activity as efficient and safe alternatives to common preservatives (such as parabens) and to combat emerging infections and drug-resistant bacterial pathogens is highly expected in cosmetics and pharmaceutics. Colloidal silver nanoparticles (NPs) are attracting interest as novel effective antimicrobial agents for the prevention of se...