The incidence of non-steroidal anti-inflammatory drug-related ulcer complications remains high despite the availability of potent anti-ulcer drugs and selective cyclo-oxygenase-2 inhibitors. Non-steroidal anti-inflammatory drug-related ulcer complications can be minimized by prospective assessment of patients' baseline risk, rational choice and use of non-steroidal anti-inflammatory drugs, and ...

The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evalu...

Purpose: This study was designed to find an answer the question, "Is it beneficial use pomegranate (POM) and tangeretin (TAN) separately or in combination, for prevention of acute gastric ulcer?". 
 Materials Methods: The gastroprotective effect determined by measuring levels selected inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β IL-10], lipid peroxid...

The plant extract of Excoecaria agallocha bark herbal preparation that has been suggested as useful in the treatment of varies diseases (anti tumor, anti microbial, anti wound killing agents and anti oxidant). In this, study to determine the gastro protective effect of E. agallocha in a model of NSAID induced ulcer rat. The lyophilized extract was given by oral gavages (125 and 62.5mg/kg) three...

It is generally believed that ulcerogenesis results from an imbalance between the aggressive and defensive factors (1). Recently, increasing interest is being shown regarding the importance of anti-ulcer therapy, presumably via the positive effects on the defensive mechanisms. Attention has been paid to the function of mucosubstances including sulfated mucosubstances (SMS) as participators in t...

BACKGROUND Despite the widespread use of roots of Cassia sieberiana in managing several health conditions including gastric ulcer disease, there is little scientific data to support the rational phytotherapeutics as an anti-ulcer agent. This paper reports an evaluation of the in vivo anti-oxidant properties of an aqueous root bark extract of C. sieberiana in experimental gastric ulcer rats in a...

Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress. Boswelia dalzielii (BD) traditionally used treat many diseases including gastric ulcers. This study aims investigate gastroprotective activity of Boswelia dalzielii. The cytoprotective property was evaluated by using five experimental methods GU: 1. Absolu...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) can have severe gastrointestinal effects and cause peptic ulcers to bleed. Acute bleeding from oesophageal varices is a major complication of cirrhosis of the liver. AIMS To investigate the role, using a case-control study, of NSAIDs in first bleeding episodes associated with oesophageal or cardial varices in cirrhotic patients. PATI...

AIMS To investigate the impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin. METHODS In a case-control study including 111 low-dose aspirin users with peptic ulcers and 109 controls (asymptomatic aspirin users), the polymorphism (T-1676C) of the COX-1...