Background: Anti-tuberculosis drugs-induced hepatotoxicity is associated with oxidative stress. Curcumin a powerful antioxidant and has been found to protect the liver from damaging effects of The study aimed assess curative protective against induced by anti TB- drugs (Isoniazid-Rifampicin) using an experimental model Albino rabbits. Methods: rabbits(n=24) were divided into four groups. Group ...

objectives: asthma is a common chronic disease. asthma and anti-asthmatic medications have been suggested as risk factors for increased susceptibility to caries. this study was conducted to evaluate the effects of different types and forms of antihistaminic medications and the duration of drug consumption on the severity of dental caries in asthmatic children. materials and methods: this cross-...

CONTEXT Erythema induratum of Bazin (EIB) is considered to be a tuberculid reaction and consists of recurrent painful nodules. The differential diagnosis includes diseases like nodular vasculitis, perniosis, polyarteritis nodosa and erythema nodosum. CASE REPORT We report the case of a woman with EIB who developed Addison's disease during treatment with anti-tuberculosis drugs with good respo...

In view of emerging drug resistance among bacterial pathogens, including Mycobacterium tuberculosis, the development of novel therapeutic strategies is increasingly being sought. A recent paradigm in antituberculosis (anti-TB) drug development is to target the host molecules that are crucial for intracellular survival of the pathogen. We previously showed the importance of Src tyrosine kinases ...

Despite urgent need, the development, approval and availability of child-friendly anti-tuberculosis drugs lag significantly behind that of adults, with children having been ignored in anti-tuberculosis drug development research. This paper outlines possible strategies for accelerating and better integrating the development of drugs and regimens for pediatric tuberculosis (TB) into existing drug...

Otsuka has been engaged in anti-tuberculosis drug development efforts for over 30 years, and is the leading private sector funder of tuberculosis (TB) research and development. Delamanid (DLM), discovered by Otsuka's scientists, has been shown to provide benefit with respect to short-term surrogate markers and long-term treatment outcomes, and it has received regulatory approval for treatment o...

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (generally 6-9 months) and unpleasant side effects of the current drugs often lead to poor patient compliance, which in turn has resulted in the emer...

ABSTRACT
 Background : Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis infection. According to World Health Organization Report (WHO), TB was ranked as the tenth highest cause of death in world at 2016. During therapy, patients with active for category I were given Isoniazid, Rifampicin, Pyrazinamide and Ethambutol 2 months which intensive phase 4 continuation phase. Va...

Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by s...