In the present study we evaluated the effects of iodine intake on the prevalence of thyroid dysfunction, autoimmunity, and goiter in two regions with different iodine status after two years of iodization in Turkey. In total 1733 adolescent subjects were enrolled into the study (993 from an iodine-sufficient area--the Eastern Black Sea Region (group 1) and 740 from an iodine-deficient area--Midd...

Introduction and Aim: Thyroid peroxidase (TPO) is a thyroid-specific antigen, the presence of TPO antibodies known to be associated with developing hypothyroidism. In this study we aimed investigate genotypes prevalent for SNP rs2071400 gene its association development autoimmune thyroid disease. Materials Methods: This involved 43 patients hypothyroidism 44 healthy controls. Genotyping (C/T) w...

Background: The association between anemia and hypothyroidism has been recognized, although the prevalence of in hypothyroid patients varies widely studies. main objectives were to study prevalence, type, etiology primary correlate severity with hypothyroidism.Methods: This research was conducted as a case-control study. Patients newly diagnosed overt euthyroid controls totaling 170 total inclu...

The thyroid microsomal antigen (MSA) in autoimmune thyroid disease is a protein of approximately 107 kD. We screened a human thyroid cDNA library constructed in the expression vector lambda gt11 with anti-107-kD monoclonal antibodies. Of five clones obtained, the recombinant beta-galactosidase fusion protein from one clone (PM-5) was confirmed to react with the monoclonal antiserum. The complem...

yperemesis gravidarum occurs in about 1.5% of pregnancies and is more common in Asian than in white women. Many patients do not need anti thyroid drugs, except for those with severe nausea and vomiting and thyroid dysfunction after 18-20 weeks of pregnancy. The aim of the study was to determine the importance of routine assessment of thyroid function in pregnant women with hyperemesis gravidaru...

Context: Type one diabetes mellitus (T1DM) is an autoimmune disorder that is yet the most common type of diabetes in children and adolescents. Several genetic risk factors have been associated with T1DM, auto immune thyroiditis and other autoimmune disorder. Among autoimmune disorders, autoimmune thyroid disease (ATD) is the most frequent disorder associated with T1DM. Its prevalence varies dep...

The most common cause of acquired thyroid dysfunction is autoimmune disease (AITD), which commonly manifests as Hashimoto's thyroiditis (HT) or Graves' (GD). importance vitamin D (vit D) an immune modulator has recently been emphasized in several types disorders. However, its significance illnesses not fully understood. purpose this study to investigate how affects the pathophysiology hyperthyr...

OBJECTIVE To investigate the frequency of thyroid disorders (TD) in patients with chronic hepatitis C before and during interferon-alpha (IFN-α) and ribavirin (RIB) treatment. STUDY DESIGN Prospective study. PATIENTS AND METHODS We prospectively studied 65 anti-HCV and viral RNA positive patients. Free thyroxine, thyroid-stimulating hormone, and thyroid peroxidase antibodies (TPO-Ab) were s...