The octapeptide hormone angiotensin II is one of the most studied peptides with aim designing and synthesizing non-peptide mimetics for oral administration. To achieve this, cyclizations at different positions within peptide molecule has been a useful strategy to define active conformation. These studies on led discovery Sarmesin, type antagonist, breakthrough mimetic Losartan, first in series ...

BACKGROUND Current recommendations on drug treatment of hypertension for primary prevention of cardiovascular disease are primarily determined by the evidence of effectiveness, disregard the resources available and values of people, and recommend a universally fixed risk cutoff for initiating drug treatment. The guidelines may have over-estimated the willingness of the public to accept and pay ...

BACKGROUND AND AIM It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to ...

Combination therapy of hypertension with separate agents or a fixed-dose combination pill offers the potential to lower blood pressure more quickly, obtain target blood pressure, and decrease adverse effects. Antihypertensive agents from different classes may offset adverse reactions from each other, such as a diuretic decreasing edema occurring secondary to treatment with a calcium channel blo...

First drugs which were largely used for chemotherapeutically and preventive use were the sulfonamides. Sulfonamides have a wide range of pharmacological activities such as against rheumatoid arthritis, anti-hypertensive, anti-epileptic, anti-bacterial, anti-protozoal, anti-fungal, non-peptidic vasopressin receptor antagonists, antiinflammatory, and translation initiation inhibitors. These sulfo...

A 44 year old lady with primary hypothyroidism presented with massive pericardial effusion without cardiac tamponade. Pericardial tap was done twice and the effusion resolved as the hypothyroid state improved. She remained hypertensive despite the euthyroid state. She was discharged well with L-thyroxine and anti-hypertensive therapy.

UNLABELLED Hypertension is an established target for long-term stroke prevention but procedures for management of hypertension in acute stroke are less certain. Here, we analyze basic science data to examine the impact of hypertension on candidate stroke therapies and of anti-hypertensive treatments on stroke outcome. METHODS Data were pooled from 3,288 acute ischemic stroke experiments (47,8...

The hexane insoluble fraction of the Garcinia dulcis (GD) flower extract comprises mainly camboginol and morelloflavone which possess potent in vivo vitro antioxidant properties. This study aimed to evaluate effects 4-week oral administration GD on arterial blood pressure (ABP) excretory function kidney 2-kidneys-1-clip (2K1C) renovascular hypertensive rats (total=12) compared sham operated (SO...

Hypertension is a common chronic condition that affects approximately 78,000,000 adults within the United States [1]. Hypertensive crisis is defined as severe hypertension with a blood pressure of greater than 180/120 mmHg, and may be further classified as urgency or emergency [2,3]. Hypertensive urgency occurs in the setting of days to weeks and patients present most commonly with a headache. ...