Patients with Alzheimer's disease after an initial response to cholinesterase inhibitors may complain a later lack of efficacy. This, in association with incident neuropsychiatric symptoms, may worsen patient quality of life. Thus, the switch to another cholinesterase inhibitor could represent a valid therapeutic strategy. The aim of this study was to investigate the effectiveness of the switch...

This report assesses the value of cholinesterase (ChE) activity as an indicator of liver function and analyses its usefulness in the diagnosis of jaundice. A rapid method of determination has been used, and alterations in ChE activity in conditions other than liver disease have been studied to permit a fuller and more accurate survey of its value as a liver function test. The level of serum cho...

This study concerns the distribution of cholinesterases in human skin. Previous work on this subject was published last year by Hurley, Shelley and Koelle (1) These authors used a method originated by Koelle (2, 3). In Koelle's method, acetyithiocholine and butyryithiocholine are used as substrates. It is assumed that acetyithiocholine is split by specific acetyicholinesterase as well as by non...

OBJECTIVE Agricultural pesticide handlers are at an elevated risk for overexposure to organophosphate (OP) pesticides, but symptoms can be difficult to recognise, making biomarkers invaluable for diagnosis. Occupational monitoring programmes for cholinesterase depression generally rely on measuring activity of either of the two common blood cholinesterases which serve as proxy measurements for ...

Molecular docking is a promising and reliable technology for the purpose of discovering lead compounds via virtual screening. In addition to allowing testing large number compounds, it also allows determination how selected inhibit targeted protein/receptor based on scoring function ranking. Because selective cholinesterase monoamine oxidase inhibitors play critical role in treatment Alzheimer'...

This report assesses the value of cholinesterase (ChE) activity as an indicator of liver function and analyses its usefulness in the diagnosis of jaundice. A rapid method of determination has been used, and alterations in ChE activity in conditions other than liver disease have been studied to permit a fuller and more accurate survey of its value as a liver function test. The level of serum cho...

Most investigations of possible metabolic aberrations in childhood schizophrenia failed to demonstrate differences between schizophrenic patients and control groups. Cholinesterase activity has net been previously reported in schizophrenic children. Similar studies with adult schizophrenics have hot been consistent, despite some reports of abnormal cholinesterase activity. The present study rep...

We estimated cholinesterase (EC 3.1.1.8) activities in erthrocytes and plasma of 443 men, 188 women not taking oral contraceptives, and 70 women who were taking oral contraceptives. Men in the first six decades of life had higher plasma cholinesterase activity than did women who were not taking oral contraceptives, and these women had higher plasma cholinesterase activity than women taking oral...

The Kalow allele for cholinesterase is a quantitative variant of the usual gene and has been shown to result from a single base pair change in the DNA. A new method based on the polymerase chain reaction to distinguish Kalow alleles of the cholinesterase gene was developed. Using the amplification refractory mutagenesis system, two different reactions distinguished the presence of a guanine (no...