نتایج جستجو برای: antagonistic peptide

تعداد نتایج: 171088  

Journal: :Science 2013
Jefri Heyman Toon Cools Filip Vandenbussche Ken S Heyndrickx Jelle Van Leene Ilse Vercauteren Sandy Vanderauwera Klaas Vandepoele Geert De Jaeger Dominique Van Der Straeten Lieven De Veylder

The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional...

Journal: :iranian journal of nuclear medicine 2008
mostafa gandomkar reza najafi mohammad mazidi mostafa goudarzi seyed esmaeil sadat ebrahimi

introduction: over expression of selected peptide receptors in human tumors has been shown to represent clinically relevant targets for cancer diagnosis and therapy. the aim of this work was to investigate neuropeptide y (npy) as a new radiopharmaceutical for diagnosis of breast cancer. methods: a neuropeptide y analogues with y1 receptor preference and agonistic properties was synthesized by s...

Journal: :modares journal of medical sciences: pathobiology 2013
ali mota abbas lotfi jalal barzin mohammad massumi mostafa hatam

objective: in this study we introduced an rgd-containing peptide of collagen iv origin that possesses potent cell adhesion and proliferation properties. this peptide was immobilized on a nanofibrous polycaprolactone/gelatin scaffold after which we analyzed human bone marrow-derived mesenchymal stem cells (hbmscs) adhesion and proliferation on this peptide-modified scaffold. methods: nanofibrous...

Journal: :iranian journal of pharmaceutical research 0
amir mortazavian department of food technologyresearch, national nutrition and food technology research institute, shahid beheshti university of medical sciences, p.o. box 19395-4741, tehran, iran.

milk is an important component of a balanced diet and contains many valuable constituents. a considerable part of the milk healthbenefits is related to its proteins, not only for their nutritive value but also for their biological properties. scientific evidence suggests that anticarcinogenic activities, antihypertensive properties, immune system modulation, and other metabolic features of milk...

2010
Zoulfia Darieva Anne Clancy Richard Bulmer Emma Williams Aline Pic-Taylor Brian A. Morgan Andrew D. Sharrocks

Transcriptional control is exerted by the antagonistic activities of activator and repressor proteins. In Saccharomyces cerevisiae, transcription factor complexes containing the MADS box protein Mcm1p are key regulators of cell cycle-dependent transcription at both the G2/M and M/G1 transitions. The homeodomain repressor protein Yox1p acts in a complex with Mcm1p to control the timing of gene e...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1982
R Maurer B H Gaehwiler H H Buescher R C Hill D Roemer

The somatostatin analog D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-NH-CH(CH2OH)CHOHCH3 (SMS 201-995) displaces [3h[naloxone from its binding sites (IC50, 38 +/- 60 nM), being more than 200 times more potent than somatostatin. As measured by the difference between [3H]dihydromorphine, [3H][D-Ala2,D-Leu5]enkephalin, and (-)-[3H]bremazocine binding, SMS 201-995 appears to be highly specific for the opiate mu...

Journal: :iranian journal of nuclear medicine 2011
seyed pezhman shirmardi mostafa erfani mohammad mazidi

introduction: bombesin is a 14-aminoacid peptide isolated from frog skin. the mammalian counterparts of the frog peptide are neuromedin b (nmb) and gastrin-releasing peptide (grp). bombesin (bbn) is a peptide showing high affinity for the gastrin releasing peptide receptor (grpr). prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over express receptors to bombesi...

Journal: :The Journal of pharmacy and pharmacology 2000
B Fuchs K Breithaupt-Grögler G G Belz S Roll C Malerczyk V Herrmann H Spahn-Langguth E Mutschler

The angiotensin II antagonistic effects of candesartan and losartan were compared in-vivo after single and repeated doses. Effects were related to antagonistic activity in plasma. In this double-blind, crossover study, 12 healthy male volunteers received, in random order, daily oral doses of 8 mg candesartan cilexetil or 50 mg losartan for seven days. On day 1 and day 8, dynamics and kinetics w...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...

Journal: :International archives of allergy and immunology 2012
Yoshinori Matsuwaki Kota Wada Thomas White Hiroshi Moriyama Hirohito Kita

RATIONALE Recent studies suggest that host immune responses to environmental fungi may play an important role in the development of allergic diseases, such as human asthma. Epithelium is considered an active participant in allergic inflammation. We previously reported that aspartate protease from Alternaria induces the activation and degranulation of human eosinophils that are mediated through ...

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