نتایج جستجو برای: anp شاخص همپوشانی وزنی

تعداد نتایج: 90094  

Journal: :The Journal of endocrinology 1997
P Vaillancourt S Omer R Palfree D R Varma S Mulay

The main objective of this study was to find out if the reported changes in the aldosterone-suppressant activity of atrial natriuretic peptide (ANP) during different hormonal states in rats are due to a modulation of ANP receptors. In zona glomerulosa cells, ribonuclease protection assay detected mRNAs for guanylate cyclase (GC)-coupled ANP GC-A and GC-B receptors, and for ANP C receptors, whic...

Journal: :Physiological research 2015
M Moubarak C Magaud Y Saliba A Chatelier P Bois J-F Faivre N Fares

Atrial natriuretic peptide antifibrotic properties are mainly described in cardiac myocytes or in induced cardiac myofibroblasts (Angiotensin II or TGF-beta induced differentiation). In the present work, we investigate the effects of ANP/NPRA/cGMP system in modulating rat cardiac fibroblasts function. Cardiac fibroblasts were isolated from adult Wistar male rats and cultured in the presence of ...

Journal: :The Journal of clinical investigation 2005
Fitz-Roy E Curry

Atrial natriuretic peptide (ANP) acts acutely to reduce plasma volume by at least 3 mechanisms: increased renal excretion of salt and water, vasodilation, and increased vascular permeability. Authors of a study in this issue of the JCI performed a knockout of the receptor for ANP in vascular endothelia in order to distinguish the effects of ANP-dependent increases in vascular permeability from ...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2010
Anna A Birukova Junjie Xing Panfeng Fu Bakhtiyor Yakubov Oleksii Dubrovskyi Jennifer A Fortune Alexander M Klibanov Konstantin G Birukov

Increased levels of atrial natriuretic peptide (ANP) in the models of sepsis, pulmonary edema, and acute respiratory distress syndrome (ARDS) suggest its potential role in the modulation of acute lung injury. We have recently described ANP-protective effects against thrombin-induced barrier dysfunction in pulmonary endothelial cells (EC). The current study examined involvement of the Rac effect...

Journal: :Circulation research 1992
E Suzuki Y Hirata O Kohmoto T Sugimoto H Hayakawa H Matsuoka M Kojima K Kangawa N Minamino

To investigate the cellular mechanism for the synthesis and secretion of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), we examined the effects of vasoactive agents on the secretion rates and gene expression of ANP and BNP in cultured rat atrial cells. Endothelin (10(-7) M, +61%), 12-O-tetradecanoylphorbol 13-acetate (TPA, 10(-6) M, +62%), the calcium ionophore A23187 (10...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1986
R Quirion M Dalpé T V Dam

Both rat 125I-labeled atrial natriuretic polypeptide [125I-ANP or atrial natriuretic factor fragment ANF-(99-126)] and human 125I-ANP [125I-alpha-ANP or human ANF-(99-126)] bind with high specificity and affinity (Kd = 20-80 pM) to an apparent single class of sites in guinea pig brain. The ligand selectivity pattern demonstrates that ANF-(101-126) greater than ANF-(99-126) greater than ANF-(103...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 1999
Hiroaki Itoh Jing Zheng Ian M Bird Kazuwa Nakao Ronald R Magness

Atrial natriuretic peptide (ANP) is present in the fetoplacental circulation of humans and sheep. The ANP-A receptor is the specific membrane receptor for ANP, which produces cGMP. The clearance receptor of natriuretic peptide (CR) is postulated to modulate local concentrations of ANP, thereby modulating cGMP production through the ANP-A receptor. Recently we reported that fetoplacental basic f...

Journal: :American journal of physiology. Renal physiology 2011
Josefin Axelsson Anna Rippe Bengt Rippe

The present study was performed to investigate the effects of systemic atrial natriuretic peptide (ANP) infusion on the glomerular permeability to macromolecules in rats. In anesthetized Wistar rats (250-280 g), the left urether was cannulated for urine collection while simultaneously blood access was achieved. Rats were continuously infused intravenously with ANP [30 ng·kg(-1)·min(-1) (Lo-ANP;...

Journal: :Circulation. Arrhythmia and electrophysiology 2015
Rui Hua Sarah L MacLeod Iuliia Polina Motahareh Moghtadaei Hailey J Jansen Oleg Bogachev Stacy B O'Blenes John L Sapp Jean-Francois Legare Robert A Rose

BACKGROUND Atrial natriuretic peptide (ANP) is a hormone with numerous beneficial cardiovascular effects. Recently, a mutation in the ANP gene, which results in the generation of a mutant form of ANP (mANP), was identified and shown to cause atrial fibrillation in people. The mechanism(s) through which mANP causes atrial fibrillation is unknown. Our objective was to compare the effects of wild-...

Journal: :American journal of physiology. Renal physiology 2002
Ju-Zhong Sun Shi-Juan Chen Erum Majid-Hasan Suzanne Oparil Yiu-Fai Chen

Atrial natriuretic peptide (ANP) has negative modulatory effects on a variety of pathophysiological mechanisms; i.e., it inhibits hypoxia-induced pulmonary vasoconstriction and vascular remodeling and facilitates natriuresis and vasorelaxation in NaCl-supplemented subjects. We have previously demonstrated organ-selective potentiation of ANP in the pulmonary circulation of hypoxia-adapted animal...

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