Anorectal manometry is the most well established and widely available tool for investigating anorectal function. Anal sphincter tone can be quantified by anorectal manometry. The anorectal sensory response, anorectal reflexes, rectal compliance, and defecatory function are also assessed by anorectal manometry. This report will focus on defining parameters for measurement and interpretation of a...

OBJECTIVE To assess the clinical and economic consequences of different diagnostic strategies in newborns with suspected occult spinal dysraphism. METHODS A decision-analytic model was constructed to project the cost and health outcomes of magnetic resonance imaging (MRI), ultrasound (US), plain radiographs, and no imaging in newborns with suspected occult spinal dysraphism. Morbidity and mor...

AIM The aim of this study is to evaluate postoperatively bowel symptoms of antegrade colon enema through appendicostomies in preschool children with anorectal malformation (ARM). METHOD 164 children with ARM operated on with posterior sagittal anorectal plasty were included. The malformations were classified according to Krickenbeck classification. Seventeen children in preschool age had an a...

Currarino syndrome is characterized by anorectal malformation, a presacral tumor and sacralmalformation. A funnel-shaped anal stenosis causes chronic constipation resulting in the development of megarectum and requires surgical intervention. We present a three-year-old girl with Currarino syndrome consisting of a presacral tumor, anal stenosis andmegarectum associatedwith the thickening of the ...

Purpose This study was performed to investigate the expression pattern of Wnt inhibitory factor 1 (Wif1) and β-catenin during anorectal development in normal and anorectal malformation (ARM) embryos and the possible role of Wif1 and β-catenin in the pathogenesis of ARM. Methods ARM was induced with ethylenethiourea on the 10th gestational day in rat embryos. Cesarean deliveries were performed...