Atherosclerosis can be defined as the development of abnormal fat deposits in the artery wall. Atherosclerotic lesions are believed to progress through a focal, lipid-filled foam cell stage (fatty streak) into an advanced, complicated lesion that contains abundant extracellular cholesterol ester in the atheromatous gruel within the arterial intima. Weakening of the arterial wall and/or rupture ...

25 26 27 28 29 30 This study describes a rapid method for identifying bacteria which convert free linoleic acid to conjugated linoleic acid (CLA). The method is based on the spectrophotometric detection of CLA and compares well to the standard GLC method. This method should facilitate the high throughput screening of bacterial isolates for the ability to produce conjugated fatty acids.

In this paper we describe a rapid method for identifying bacteria which convert free linoleic acid to conjugated linoleic acid (CLA). This method is based on spectrophotometric detection of CLA and compares well with the standard gas-liquid chromatography method. This method should facilitate high-throughput screening of bacterial isolates for the ability to produce conjugated fatty acids.

The CLA story began with the discovery by Pariza and co-workers that fat extract from ruminants contained compounds that possessed anticarcinogenic activity. They subsequently identified these compounds as conjugated dienoic isomers of linoleic acid and coined the term conjugated linoleic acid or CLA (see review 1). Over the last decade the published research on the biology of CLA has increased...

Adipose tissue may be the source of insulin desensitizing proinflammatory molecules that predispose to insulin resistance. This study investigated whether dietary fatty acids could attenuate the proinflammatory insulin-resistant state in obese adipose tissue. The potential antidiabetic effect of cis-9, trans-11-conjugated linoleic acid (c9,t11-CLA) was determined, focusing on the molecular mark...

Maternal adipose tissue is a major contributor to breast milk long-chain fatty acids, probably through the pool of plasma NEFA. The fatty acid composition of the erythrocyte membrane (EM) is a biochemical index of the intake of fatty acids not synthesized endogenously and of PUFA and long-chain PUFA fatty acid status. The present study investigated the associations between breast milk fatty aci...

Bone destruction is a pathological hallmark of several chronic inflammatory diseases, including rheumatoid arthritis, periodontitis, and osteoporosis. Inflammation-induced bone loss of this sort results from increased numbers of bone-resorbing osteoclasts. Numerous studies have indicated that conjugated linoleic acid (CLA) positively influences calcium and bone metabolism. Gene-deletion studies...

and Implications A study was initiated to research the efficacy of feeding conjugated linoleic acid (CLA) to market barrows to achieve improvements in growth, carcass, and pork quality characteristics. The feeding of CLA at a constant level (0.75%) from 40 kg to 115 kg of body weight resulted in a significant increase in subjective marbling scores and tended to increase subjective firmness scor...