Abstract P53 is frequently mutated in most human cancers, including glioblastoma (GBM). Many p53 mutants acquire gain-of-function oncogenic effects through only partially understood mechanisms. To investigate the role of mutant (MUT-p53) GBM, we performed ChIP-seq wildtype (WT-p53) and MUT-p53 GBM cell lines. Among 2834 unique peaks reads cells, found 242 long non-coding RNAs (lncRNAs) with up ...

The human population has increased considerably worldwide, including in the Philippines. Aquaculture is one of main food sectors that provides a cheap source protein Changes diet composition aquaculture have brought about concerns regarding certain negative effects at gastrointestinal levels. replacement fish meal with plant considerable proportion majority cultured species led to proliferative...

Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation ...

A number of different compounds, including phenobarbital, hypolipidemic drugs such as clofibrate and nafenopin, the sex steroids progesterone, cyproterone acetate, estradiol and mestranol, chlorinated hydrocarbons such as DDT, hexachlorocyclohexane, and TCDD and the antioxidant butylhydroxytoluene, appears to promote the development of liver tumors from previously induced initiated cells. The m...

By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some case...