To clarify the possible involvement of uninhibited angiotensin II (Ang II) type 2 (AT(2)) receptor stimulation in the effects of an Ang II type 1 (AT(1)) receptor blocker, valsartan, we examined the cardiovascular remodeling induced by aortic banding with the use of wild-type (Agtr2+) and AT(2) receptor null (Agtr2-) mice. Aortic banding caused cardiac hypertrophy in Agtr2+ and Agtr2- mice to a...

A relatively recent concept is that vascular dysfunction plays a key role in cognitive impairment, as well as stroke. Impaired neurovascular coupling, probably in part through activation of the angiotensin II type 1 receptor, is central to cerebrovascular dysfunction.1 Reactive oxygen species clearly are important mediators of the deleterious vascular effects of angiotensin II. The evidence see...

ROS: Reactive Oxygen Species; RAS: Renin Angiotensin System; PKC-Δ: Protein Kinase C-Δ; NOX: NADPH Oxidase; BK Channels: Ca2+ Activated Potassium Channels; RAAS: Renin Angiotensin Aldosterone System; Caox: Calcium Oxalate; ACE2: Angiotensin-Converting Enzyme 2; Ang II: Angiotensin II; EMT: Epithelial To Mesenchymal Transition; AT1R :Ang II Type 1 Receptor; CKD: Chronic Kidney Disease; L-NAME: N...

OBJECTIVE To investigate the fetal angiotensin II type 1 receptor genotype in pre-eclampsia. DESIGN Case-control study. POPULATION Forty-one maternal-fetal pairs from pre-eclamptic pregnancies and 80 maternal-fetal pairs from normotensive pregnancies. METHODS Maternal and fetal DNA was genotyped at three diallelic polymorphisms, at nucleotides 573, 1062, and 1166, in the coding exon of th...

We have demonstrated that the reduction of angiotensin II effects during the nephrogenic period reduces the nephron number and induces the development of hypertension. The hypotheses examined are that this reduction of angiotensin effects leads to the development of an age-dependent sodium sensitive hypertension and that the hypertension is angiotensin II dependent. Newborn rats were treated wi...

OBJECTIVE Angiotensin II has been implicated in the pathogenesis of the vascular complications of insulin resistance. Recently, serine phosphorylation and degradation of insulin receptor substrate-1 (IRS-1) were shown to inhibit Akt activation and reduce glucose uptake. Therefore, we examined the effects of chronic angiotensin II treatment on IRS-1 phosphorylation and protein expression in vasc...