Cutaneous absorption of nitroglycerin is a well-documented phenomenon which may have unique advantages for the sustained prophylaxis of angina pectoris. Therefore, we have examined the effects of nitroglycerin ointment and placebo on exercise capacity in 14 patients with angina pectoris. Nitroglycerin ointment produced a significant increase in exercise capacity which persisted for at least thr...

Cutaneous absorption of nitroglycerin is a well-documented phenomenon which may have unique advantages for the sustained prophylaxis of angina pectoris. Therefore, we have examined the effects of nitroglycerin ointment and placebo on exercise capacity in 14 patients with angina pectoris. Nitroglycerin ointment produced a significant increase in exercise capacity which persisted for at least thr...

Liquid crystals, encapsulated onto black Mylar tapes, were used as cutaneous temperature sensors in 50 male patients, who had thermographic examinations while they were being exercised on the treadmill, in an attempt to induce angina pectoris. Twenty-eight of the group remained free of pain and the exercise thoracic thermogram was essentially unchanged from the control or resting state. Twenty-...

Refractory angina, also described as chronic refractory angina pectoris (CRAP), classically occurs in patients with advanced, often diffuse coronary artery disease (CAD) that failed to be completely revascularized by percutaneous coronary intervention (PCI) and/or coronary artery bypass graft (CABG) with remaining angina pectoris symptoms despite maximized pharmacological intervention. In the m...

BACKGROUND Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal and antiischemic effects of ivabradine, a new heart rate-lowering agent that acts specifically on the sinoatrial node. METHODS AND RESULTS In a double-blind, placebo-controlled trial, 360 patients with ...

Angina pectoris is a common disabling disorder and a clinical syndrome, caused by myocardial ischemia; an imbalance between myocardial oxygen supply and myocardial oxygen consumption. Thus, ischemia produces a typical series of events such as metabolic and biochemical alterations which lead to impaired ventricular relaxation and diastolic dysfunction, impaired systolic function, and electrocard...

The duration of action of single oral doses of 80 and 160 mg of propranolol during acute and sustained therapy was studied in nine patients with stable, exercise-induced angina pectoris. Plasma propranolol levels peaked 2 hours after both doses during acute and sustained therapy, but there were wide variations between individuals in plasma concentration with both dosage schedules. Plasma half-l...

A prospective study utilizing a comprehensive medical regimen is reported in 133 patients with severe angina pectoris due to coronary artery disease. Marked amelioration of pain, increase in exercise tolerance and improvement in ischemic exercise+lectrorardiographic patterns were observed in 90.2 percent of the patients in response to titrated doses of propranolol and sublingual isosorbide dini...