Leptolstatin, a product from Streptomyces sp. SAM1595, is a gap phase-specific inhibitor of the mammalian cell cycle. Physico-chemical properties and spectrometric analyses showed that the structure of leptolstatin is (2Z,6E,8Z,12E,14E,22E)-19,24-dihydro xy-8,10,14,16,18,20,22-heptamethyl-17-oxo-2 , 6,8,12,14,22-tetracosahexaen-5-olide.

A novel solvent-free solid-state synthesis was used to prepare a non-crystalline polysilsesquioxane sample, with a peculiar viscous form. The material was synthesized through direct self-condensation of a partially condensed polyhedral oligomeric silsesquioxane (POSS) and its physico-chemical properties, in terms of composition/structure, thermal stability and hydrophobicity, were investigated.

The present study explored the possibility of generating a novel sensory evaluation instrument for describing comprehensive food palatability via its subdomains (rewarding, cultural, and informational) while keeping physiological factors constant. Seventy-five Japanese participants were asked to taste cheese samples and to respond to a questionnaire that was developed to dissect the distinct su...

Understanding the removal mechanisms and kinetics of trace tetracycline by activated sludge is critical to both evaluation of tetracycline elimination in sewage treatment plants and risk assessment/management of tetracycline released to soil environment due to the application of biosolids as fertilizer. Adsorption is found to be the primary removal mechanism while biodegradation, volatilization...

The arrangement of molecules in molecular networks determines their physical and chemical properties. Addressing this fundamental issue requires proper structural characterization tools. Due to an overlap, interdigitation, tilting or stacking of molecules revealing the structure of the networks is challenging. Tebi et al (2015 Nanotechnology 27 025704) developed a clever approach that enables a...

Biological tests are necessary for studying the toxicity and biochemical effects of pesticides to individual species in the animal and plant kingdoms as well as for indirect determination of biologically important physical and chemical properties of pesticides. Some of the more important requisites for meaningful application of biological tests are careful method standardization; use of sensiti...

In a recent paper, we presented a linear scaling Kohn-Sham density functional theory (DFT) code based on Daubechies wavelets, where a minimal set of localized support functions are optimized in situ and therefore adapted to the chemical properties of the molecular system. Thanks to the systematically controllable accuracy of the underlying basis set, this approach is able to provide an optimal ...

Improving the profile of a molecule for the drug-discovery process requires the simultaneous optimization of numerous, often competing objectives. Traditionally, standard chemoinformatics methods ignored this problem and focused on the sequential optimization of each single biological or chemical property (ie, a single objective). This approach, known as single-objective optimization (SOOP), st...

The four diastereoisomers of cyclo(-Asp-Val-) were synthesized to compare with a proposed structure of cairomycin A. Their antimicrobial activities were determined against both Gram-positive and Gram-negative bacteria. The physico-chemical properties of the isomers were characterized by mp, 1H NMR, IR, FAB-MS, and solubility in solvents, which were different from those reported for cairomycin A.

Graphene's unique physical and chemical properties make it an attractive platform for use in micro- and nanoelectronic devices. However, electrostatically controlling the flow of electrons in graphene can be challenging as a result of Klein tunneling, where electrons normally incident to a one-dimensional potential barrier of height V are perfectly transmitted even as V → ∞. In this study, theo...