TREX2 is an autonomous nonprocessive 3' --> 5' exonuclease, suggesting that it maintains genome integrity. To investigate TREX2's biochemical and cellular properties, we show that endogenous TREX2 is expressed widely in mouse tissues and human cell lines. Unexpectedly, endogenous human TREX2 is predominantly expressed as a 30-kDa protein (not 26 kDa, as previously believed), which is likely enc...

Creatine deficiency syndromes are a newly described group of inborn errors of creatine synthesis (arginine:glycine amidinotransferase (AGAT) deficiency and guanidinoacetate methyltransferase (GAMT) deficiency) and of creatine transport (creatine transporter (CRTR) deficiency). The common clinical feature of creatine deficiency syndromes is mental retardation and epilepsy suggesting main involve...

A pyrethroid-resistant strain of the diamondback moth, Plutella xylostella (L.), originally collected in Thailand showed cross-resistance to all the pyrethroids tested. Upon further selection with fenvalerate in the laboratory, the strain exhibited an extremely high LD50 value, 41 μg/larva, for fenvalerate. In genetic studies of the resistance, the F1 progeny showed recessive gene(s), while the...

Non-alcoholic fatty liver disease (NAFLD) is a condition associated with metabolic disturbances. The aim of the present study was to investigate the biochemical characteristics and risk factors for NAFLD. The study was carried out in a total of 881 subjects diagnosed by ultrasonography. NAFLD occurred mainly in middle-aged individuals, with a prevalence of 63.1 per cent. Multiple logistic regre...

BACKGROUND Postoperative sellar hematoma can develop following surgery for pituitary tumors and other sellar masses such a Rathke's cleft cyst (RCC) due to continued blood oozing. Though often mild sellar hematoma can create mass effects that might impair pituitary function. AIM This study summarizes the clinical and biochemical characteristics of sellar hematoma and explores the potential me...

A successful enhanced biological phosphorus removal (EBPR) was observed in both anaerobic-aerobic sequencing batch reactor (An-Ox SBR) to induce growth of phosphorus accumulating organism (PAO) and anaerobic-anoxic (An-Ax) SBR to induce growth of denitrifying PAO (DPAO). Although the EBPR performance of An-Ox SBR was higher by 11.3% than that of An-Ax SBR, specific phosphorus release rates in t...

Yersinia enterocolitica was isolated from human mesenteric lymph nodes. Its morphological characteristics and biochemical and serological reactions are described.

Transmission of specific immunoglobulins from mothers to their offspring via the egg is a common phenomenon in egg-laying vertebrates but the occurrence of this phenomenon in reptiles, especially in colubrid snakes, has not been proven until recently. Thus, the essential biochemical characteristics of antibodies deposited in eggs of Elaphe guttata (Colubridae, Serpentes) were studied after isol...

The epidemiology and possibly the etiology of bovine spongiform encephalopathy (BSE) have recently been recognized to be heterogeneous. In particular, three types [classical (C) and two atypical (H, L)] have been identified, largely on the basis of characteristics of the proteinase K (PK)-resistant core of the misfolded prion protein associated with the disease (PrP(res)). The present study was...

OBJECTIVE To determine the clinical and biochemical characteristics of children with Juvenile Idiopathic Arthritis (JIA) at a tertiary care centre in Karachi, Pakistan. STUDY DESIGN A descriptive study. PLACE AND DURATION OF STUDY Paediatric Rheumatology Clinic of The Aga Khan University Hospital (AKUH), Karachi, from January 2008 to December 2011. METHODOLOGY Clinical and laboratory prof...