Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1). Objective: To identify the relative levels of IL-27 and IL-17A in MS disease. Method: In a case-control study, venous blood was c...

ABSTRACT Introduction: Interleukin-18 (IL-18) is a proinflammatory cytokine that is produced in adipose tissue and skeletal muscle. The circulating levels of IL-18 increases in obesity and some metabolic and cardiorespiratory diseases. The aim of the present study is to investigate the relationship between circulating levels of IL-18 and leptin, high-sensitivity C-reactive protei...

background: interleukin-27 is a heterodimeric cytokine belonging to il-12 and il-23 families, secreted  by antigen presenting cells( apcs ) .the il-27 is composed of 2 subunits: epstein-barr virus induced gene 3 (ebi3) and p28. il-27 is an anti-inflammatory cytokine which has an inhibitory effect on th17 population and suppress the il-17 expression. it is suggested that il-27 could be a potent ...

background and aims. streptococcus mutans is an important species in oral microflora and its components have been found to stimulate production of proinflammatory cytokines in dental caries. the aim of this study was to evaluate proin-flammatory cytokines (il-1α and il-6) in patients with s. mutans. materials and methods. seventy samples were selected during pulpectomy and investigated for the ...

cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

background: periodontitis is a multifactorial chronic inflammatory disease characterized by destruction of tooth-supporting tissues. environmental and genetic factors as well as the immune system participate in this process. recent studies have attempted to elucidate the role of cytokine networks involved in periodontal diseases. objective: to assess and compare the levels of il-4, il-6 and il-...

background: in this study the level of il-23 and il-27 produced by macrophages derived from peri­pheral blood mononuclear cell culture collected from patients with healing or non-healing form of cutane­ous leishmaniasis lesion were compared before and after treatment with live leishmania to explore whether il-23 or il-27 plays any role in healing process of cutaneous lesions induced by l. major...

Objective(s): In addition to pro-inflammatory role, dendritic cells (DCs) can also be anti-inflammatory when they acquire tolerogenic phenotype. In this study we tested the role of CD40 and IL-23p19 in antigen presenting function of bone marrow-derived DCs (BMDCs) by comparing BMDCs derived from CD40 knockout (CD40KO-DCs) and IL-23p19 (IL-23p19KO-DCs) knockout mice wit...

background: schizophrenia is a disorder of the executive function of both sensory and central nervous system. recent studies suggest that immune mechanisms play a role in the pathophysiology of this disease. the variations in cytokine concentrations have been associated with psychopathology and treatment of schizophrenia. objective: to investigate the changes in serum concentrations of tnf- α, ...

allergic rhinitis (ar) is one of the most common chronic diseases in the developed countries. this study was performed to investigate the effect of cpg-odn in alteration of t-helper (th)1/th2 balance of patients with ar treated with intranasal corticosteroids (incs) and antihistamines. peripheral blood mononuclear cells (pbmcs) of 20 patients with ar were isolated before and after 45 days thera...