i was glancing at the proceedings of the 3rd national meeting of iranian association of medical editors of december 2010, few points took my attention worth mentioning. of the 173 medical science journals of iran only 54 are registered in the scopus database.1   at this gathering all the talks had been focused on the improvement of the quality and impact factors (if) which is the score that the...

An important goal is to identify the direct activation domain (AD)-interacting components of the transcriptional machinery within the context of native complexes. Toward this end, we first demonstrate that the multisubunit TFIID, SAGA, mediator, and Swi/Snf coactivator complexes from transcriptionally competent whole-cell yeast extracts were all capable of specifically interacting with the prot...

RATIONALE Bunyaviruses have become a major threat to both humans and livestock in Europe and the Americas. The nucleocapsid (N) protein of these viruses is key to the replication cycle and knowledge of the N oligomerisation state is central to understanding the viral lifecycle and for development of therapeutic strategies. METHODS Bunyamwera virus and Schmallenberg virus N proteins (BUNV-N an...

Rhp14 of Schizosaccharomyces pombe is homologous to human XPA and Saccharomyces cerevisiae Rad14, which act in nucleotide excision repair of DNA damages induced by ultraviolet light and chemical agents. Cells with disrupted rhp14 were highly sensitive to ultraviolet light, and epistasis analysis with swi10 (nucleotide excision repair) and rad2 (Uve1-dependent ultraviolet light damage repair pat...

Leptospirosis is a worldwide zoonosis caused by pathogenic Leptospira. The whole-genome sequence of L. interrogans serovar Copenhageni together with bioinformatics tools represent a great opportunity to search for novel antigen candidates that could be used as subunit vaccine against leptospirosis. We focused on six genes encoding for conserved hypothetical proteins predicted to be exported to ...

Intracellular delivery of functional macromolecules using peptide transduction domains (PTDs) is an exciting technology with both experimental and therapeutic applications. Recent data indicate that PTD-mediated transduction occurs via fluid-phase macropinocytosis involving an intracellular pH drop to approximately 5. Nitrilotriacetic acid (NTA)-coordinated metals avidly bind hexahistidine-tagg...

This paper places Husserl’s mature work, The Crisis of the European Sciences, in the context of his engagement with—and critique of—experimental psychology at the time. I begin by showing (a) that Husserl accorded psychology a crucial role in his philosophy, i.e., that of providing a scientific analysis of subjectivity, and (b) that he viewed contemporary psychology—due to its naturalism—as hav...

the rate of scientific articles published in scientific journals is one of the indicators of assessing the status of science and technology. an increase in these publications is a sign of the movement of the society towards development and promotion. in this article, the rate of scientific publications in scientific journals (types a and b) during the years 2002 and 2003 will be analyzed. in or...

The discovery of the Antarctic ozone hole and anthropogenic climate change has thrust the atmospheric sciences into the forefront of scientific disciplines, and such findings routinely appear on the front pages of the media and on the desks of world leaders. Two events can be cited as examples of the ascendency of the atmospheric sciences. First was the award of the 1995 Nobel Prize in Chemistr...