10.1083/jcb/1722iti3jcb1722iti3Sometimes size does matter D uring myofi broblast differentiation in vitro, “supermature” focal adhesions (FAs) arise due to increased physical stress, report Goffi n et al. (page 259). Additionally, increased tension induces accumulation of αsmooth muscle actin (α-SMA) in stress fi bers that are anchored at these FAs. In vivo, the extracellu...