In this paper, a new generalization of the half-normal distribution which is called the perturbed half-normal distribution is introduced. The new distribution belongs to a family of distributions which includes the half-normal distribution along with an extra parameter to regulate skewness. The probability density function (pdf) is derived and some various properties of the new distribution are...

The remarkable scientific work on fertility preservation that is documented in the early chapters of this volume will inevitably give rise to moral and religious questions about the use of technology to reproduce. In this regard, oncofertility is no different from other forms of assisted reproduction that have led to extensive debate among ethicists and moral theologians. In the case of many fo...

Background. There is a need in primary care for simple asthma outcome measures that are valid in terms of their relationship with lung function and capable of predicting those patients for whom additional management is indicated. Aim. To assess the predictive validity of a revised asthma morbidity index in United Kingdom (UK) general practice. Method. Morbidity index and peak flow rate data wer...

A major unresolved question for the 11q23 translocations involving MLL is the chromosomal mechanism(s1 leading to these translocations. We have mapped breakpoints within the 8.3-kb BamHl breakpoint cluster region in 31 patients with acute lymphoblastic leukemia and acute myeloid leukemia (AML) de novo and in 8 t-AML patients. In 23 of 31 leukemia de novo patients, MLL breakpoints mapped to the ...

Using a Bayesian learning model with heterogeneity across agents, our study aims to identify the relative importance of alternative pathways through which professional forecasters disagree and reach consensus on the term structure of inflation and real GDP forecasts, resulting in different patterns of forecast accuracy. Forecast disagreement arises from two primary sources in our model: differe...