Forty-four patients with metastatic breast cancer who had previously received extensive conventional systemic therapy, including combination chemotherapy with doxorubicin, were treated with Bisantrene, a new anthracene derivative. The dose schedule was 250 to 300 mg/sq m body surface administered as a 1- to 2-hr i.v. infusion. Of 40 evaluable patients, there were nine partial responses, and 18 ...

BACKGROUND We report a case of an urticarial reaction after drinking alcohol beverages. The patient was a 47-year-old man suffering urticarial and anaphylactoid reaction to alcohol for two years. These reactions were observed at every alcohol beverages intake. CASE SUMMARY We performed a prick test with diluted ethanol, alcohol beverages and their metabolites (acetaldehyde, acetic acid). Only...

The scombroid poisoning is due to the ingestion of poorly preserved fish (especially tuna, sardines, and mackerel) out of the cold chain. Under the influence of the proliferation of gram negative bacteria that occurs for heating, the histidine content in the muscle of the fish is converted into histamine, by the action of the enzyme histidine decarboxylase. If the histamine is ingested in large...

Administration of the relatively organ specific antibody, so called nephrotoxin, present in anti-kidney serum, is followed by a diffuse glomerulonephritis. This is characterized early by swelling of the intercapillary substance of the glomerular tuft and by tubular degeneration. Fibrin thrombi are only present in the glomerular capillaries when the injection of anti-kidney serum results in a se...

SUMMARY The administration of low molecular weight dextran resulted in an increase in hepatic metastases in rabbits receiving intra portal inoculations of V2 carcinoma cells. This effect is similar to that observed previously in our laboratory following intra portal injection of Walker tumor cells in the rat. Although the mechanism whereby dextran produces such an effect on tumor growth is uncl...

Introduction: The transfusion of blood and components is a life-saving procedure in clinical practice. However, it associated with risks that can range from trivial self-limited Allergic Reactions (AR) to life endangering anaphylactic or haemolytic reactions. Aim: To analyse the pattern incidence related adverse events develop preventive strategies. Materials Methods: This was retrospective, ob...

Angioedema can be caused by either mast cell degranulation or activation of the kallikrein-kinin cascade. In the former case, angioedema can be caused by allergic reactions caused by immunoglobulin E (IgE)-mediated hypersensitivity to foods or drugs that can also result in acute urticaria or a more generalized anaphylactic reaction. Nonsteroidal anti-inflammatory drugs (cyclooxygenase 1 inhibit...

The genetics of natalizumab hypersensitivity One learns to itch where one can scratch Many of the immune therapies that are currently approved or in development for patients with multiple sclerosis (MS) are potentially immunogenic recombinant proteins. 1 Some of these proteins have amino acid substitutions, while others may differ from their endogenous counterparts by posttransla-tional modific...