Recently, we developed a series of cytotoxic peptide conjugates containing 14-O-glutaryl esters of doxorubicin (DOX) or 2-pyrrolino-DOX (AN-201). Serum carboxylesterase enzymes (CE) can partially hydrolyze these conjugates in the circulation, releasing the cytotoxic radical, before the targeting is complete. CE activity in serum of nude mice is about 10 times higher than in human serum. Thus, w...

although the status of women in dramatic literature of resistance has always been criticized by critics and researchers of theatre in our country, there has been no change in the authors’ approach or their policy making. it seems that despite diagnosing the problem researchers and writers feel uncertain in how to tackle the problem and change the conditions. the main reason is the lack of knowl...

In this paper, we describe the effectiveness of utterance generation using causal knowledge for a dialogue system. Recently, there has been a variety of research on non-taskoriented dialogue systems; however, an effective approach has not yet been developed. One of the most important reasons for this is that non-task-oriented dialogue systems lack common sense knowledge, which is not in their d...

At the 2008 Lambeth Conference, The Principles of Canon Law Common to Churches Anglican Communion were launched. For first time, detailed principles canon law made manifest, fruit earlier research by legal academic Norman Doe. As early as 2002, Primates had recognised that ‘the unwritten common and expressed shared may be understood constitute a fifth “instrument unity”’. project proved wellspr...