نتایج جستجو برای: amyloid

تعداد نتایج: 37689  

Journal: :European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1997
T Yamada T Miida T Yamaguchi Y Itoh

Serum amyloid A, an apolipoprotein of high density lipoproteins, is also present to a lesser degree in low density lipoproteins and is co-localized with apolipoprotein B in atherosclerotic lesions. This study examined the effect of serum amyloid A on cellular affinity of low density lipoprotein in vitro. 125I-labelled low density lipoprotein, when loaded with recombinant serum amyloid A1 (acute...

Journal: :Science translational medicine 2018
Duncan B Richards Louise M Cookson Sharon V Barton Lia Liefaard Thirusha Lane David F Hutt James M Ritter Marianna Fontana James C Moon Julian D Gillmore Ashutosh Wechalekar Philip N Hawkins Mark B Pepys

Systemic amyloidosis is a fatal disorder caused by pathological extracellular deposits of amyloid fibrils that are always coated with the normal plasma protein, serum amyloid P component (SAP). The small-molecule drug, miridesap, [(R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC)] depletes circulating SAP but leaves some SAP in amyloid deposits. This ...

Journal: :Eukaryotic cell 2014
Cho X J Chan Peter N Lipke

The Candida albicans Als adhesin Als5p has an amyloid-forming sequence that is required for aggregation and formation of model biofilms on polystyrene. Because amyloid formation can be triggered by force, we investigated whether laminar flow could activate amyloid formation and increase binding to surfaces. Shearing Saccharomyces cerevisiae cells expressing Als5p or C. albicans at 0.8 dyne/cm(2...

Journal: :Aggregate 2023

Amyloid protein aggregation represents a crucial biological process with notable physiological relevance and significant implications in disease pathology. These amyloid aggregates, characterized by their unique structures, gain variety of functions. In this review (e333), Liu his colleagues delve into the mechanisms that dictate conformational transitions assembly proteins aggregates. They ill...

Journal: :International microbiology : the official journal of the Spanish Society for Microbiology 2014
Diego Romero Roberto Kolter

The term amyloidosis is used to refer to a family of pathologies altering the homeostasis of human organs. Despite having a name that alludes to starch content, the amyloid accumulations are made up of proteins that polymerize as long and rigid fibers. Amyloid proteins vary widely with respect to their amino acid sequences but they share similarities in their quaternary structure; the amyloid f...

Journal: :Neurobiology of Disease 2015
Linda Helmfors Andrea Boman Livia Civitelli Sangeeta Nath Linnea Sandin Camilla Janefjord Heather McCann Henrik Zetterberg Kaj Blennow Glenda Halliday Ann-Christin Brorsson Katarina Kågedal

The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-β1-40 in vitro. In this study we found that patients with Alzheimer disease have increased lysozyme levels in the cerebrospinal fluid and lysozyme c...

Journal: :Nature neuroscience 2004
Martin C Herzig David T Winkler Patrick Burgermeister Michelle Pfeifer Esther Kohler Stephen D Schmidt Simone Danner Dorothee Abramowski Christine Stürchler-Pierrat Kurt Bürki Sjoerd G van Duinen Marion L C Maat-Schieman Matthias Staufenbiel Paul M Mathews Mathias Jucker

The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and dementia. In contrast to Alzheimer disease (AD), the brains of those affected by hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) show few parenchymal amyloid plaques. We found that neuronal overexpression of human E693Q A...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
G A Tennent L B Lovat M B Pepys

Extracellular deposition of amyloid fibrils is responsible for the pathology in the systemic amyloidoses and probably also in Alzheimer disease [Haass, C. & Selkoe, D. J. (1993) Cell 75, 1039-1042] and type II diabetes mellitus [Lorenzo, A., Razzaboni, B., Weir, G. C. & Yankner, B. A. (1994) Nature (London) 368, 756-760]. The fibrils themselves are relatively resistant to proteolysis in vitro b...

2010
William E. Van Nostrand

Background and Purpose—Cerebral amyloid angiopathy Type 1 is characterized by amyloid protein deposition along cerebral capillaries and is accompanied by perivascular neuroinflammation and accumulation of phospho-tau protein. Tg-SwDI mice recapitulate capillary amyloid deposition and associated neuroinflammation but lack accumulation of perivascular phospho-tau protein. Methods—Tg-SwDI mice wer...

Journal: :Archives of neurology 2012
Yafei Huang Rachel Potter Wendy Sigurdson Anna Santacruz Shirley Shih Yo-El Ju Tom Kasten John C Morris Mark Mintun Stephen Duntley Randall J Bateman

BACKGROUND The amyloid hypothesis predicts that increased production or decreased clearance of β-amyloid (Aβ) leads to amyloidosis, which ultimately culminates in Alzheimer disease (AD). OBJECTIVE To investigate whether dynamic changes in Aβ levels in the human central nervous system may be altered by aging or by the pathology of AD and thus contribute to the risk of AD. DESIGN Repeated-mea...

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