While allosteric activation of AMPK is triggered only by AMP, binding of both ADP and AMP has been reported to promote phosphorylation and inhibit dephosphorylation at Thr172. Because cellular concentrations of ADP and ATP are higher than AMP, it has been proposed that ADP is the physiological signal that promotes phosphorylation and that allosteric activation is not significant in vivo. Howeve...

Phototaxis and thermotaxis by Dictyostelium discoideum slugs on water agar were impaired by the presence in the agar of adenosine, which is a cyclic AMP receptor antagonist in aggregating amoebae. Caffeine, and presumably its analogue theophylline, inhibit cyclic AMP signalling in aggregating amoebae of D. discoideum. Both compounds perturbed slug behaviour in a similar manner to adenosine, as ...

Abstract. We present 20-year flask sample records of atmospheric CO2, ?(O2/N2), and potential oxygen (APO) from the stations Lutjewad (the Netherlands) Mace Head (Ireland), a 3-year record Halley station (Antarctica). include details our calibration procedures stability scale over time, which we estimate to be 3 per meg 11 years calibration, compatibility with international Scripps O2 scale. Th...

Abstract. Sedimentary 231Pa/230Th ratios provide clues to estimate the strength of past ocean circulation. For its estimation, understanding processes controlling distributions 231Pa and 230Th in is important. However, simulations dissolved particulate modern ocean, recently obtained from GEOTRACES project, remain challenging. Here we report a model simulation global with COCO ver4.0. Starting ...

Abstract. Morphologically similar benthic foraminiferal taxa can be difficult to separate. Aside from causing issues in taxonomy, incorrect identifications complicate our understanding of species-specific ecological preferences and result flawed palaeoenvironmental reconstructions geochemical results. Over the years, a number studies have grouped together several key Arctic–North Atlantic speci...

Abstract. TROPOMI (TROPOspheric Monitoring Instrument) measurements of tropospheric NO2 columns provide powerful information on emissions air pollution by ships open sea. This is potentially useful for authorities to help determine the (non-)compliance with increasingly stringent NOx emission regulations. We find that quality improved further recent upgrades in cloud retrieval and an optimal da...

Thermopsis turcica is an endemic species of wild legume in Türkiye. The plant produces flower pistils with unusual morphological properties. aim this study was to determine the factors controlling interesting feature plant. Particularly features meristem and that mutations two genes helps occurring number organs can cause abnormalities, This has attempted explore turcica, young bud Arabidopsis ...

Marine microplastic pollution is becoming more visible and pervasive in various aquatic environments species, including those intended for human consumption. The present study evaluated the occurrence of suspended microplastics surface waters, water column, bivalves, such as Perna viridis Atrina pectinata Sorsogon bay. Microplastics were detected all sampling sites bivalve tissue samples. Surfa...

Abstract. Computational power is very important when training Deep Learning (DL) models with large amounts of data (Wooldridge, 2021). Hence, High-Performance Computing (HPC) can be leveraged to reduce computational cost, and the Irish Centre for High-End (ICHEC) provides significant infrastructure services research development both academia industry. A portion ICHEC's HPC system has been alloc...

We made mixed mounds of vitally stained prestalk cells and unstained prespore cells, from Dictyostelium discoideum (Dd), and exposed these to external 3',5'-cyclic-AMP (c-AMP) sources. We show that prestalk cells will sort out by moving directionally toward c-AMP sources held at less than 10(-5) M c-AMP. This is evidence for cell sorting via chemotaxis. We present arguments that the natural cel...