For decades, psychiatrists worried about the adverse motor effects of antipsychotics and tried tounderstandwhat caused them and why some patients developed them and others did not. In the late 1990s, the game changed. The new atypical antipsychotics caused fewer adverse motor effects but causedmoreweight gain. At present, a large number of patients with schizophrenia experience a clinically imp...

Animal studies suggest that cannabinoid receptor agonists might enhance the effect of dopamine receptor antagonists (neuroleptics, NL) in hyperkinetic movement disorders. In Tourette syndrome, NL are the most effective drugs for the treatment of tics. Recent clinical trials demonstrated that delta-9-tetrahydrocannabinol (∆9-THC) also produces a tic-suppressing effect. In this single case study ...

R abbit syndrome is an antipsychotic-induced dyskinesia of the mouth, characterized by a fine, rapid, involuntary perioral motion that resembles the chewing motion of a rabbit.1 The oral movements occur in a vertical direction and can be differentiated from tardive dyskinesia by the lack of involvement of the tongue and by the rhythmic pattern.2 However, differentiation of tardive dyskinesia or...

Hypochondriasis (HYPO), an obsessive-compulsive spectrum disorder, is frequent in patients with schizophrenia (SCH) (20%), especially among those treated with clozapine (36.7%). Treatment options for OCS/OCD in patients under clozapine (CLZ) include combining clozapine with amisulpride/aripiprazole or a mood stabilizer, augmenting clozapine with a serotoninergic reuptake inhibitor, adding cogni...