Effects of anti-asthmatic drugs on airway resistance and plasma level of cyclic AMP were investigated in guinea pigs sensitized and non-sensitized with egg-albumin. Histamine increased airway resistance in the both groups of guinea pigs, and guinea pigs sensitized with egg-albumin were more sensitive to histamine. Anti-asthmatic drugs inhibited dose-dependently the increase of airway resistance...

Responses of Surface Arteries and Blood Flow of Ischemic and Nonischemic Cerebral Cortex to Aminophylline, Ergotamine Tartrate, and Acetazolamide • In cats in which one middle cerebral artery was occluded, cortical blood flow (CBF) was measured and the superficial cortical microvasculature was observed bilaterally before and after the intravenous injection of a vasoactive drug. Aminophylline pr...

We compared steady-state theophylline pharmacokinetics in 13 healthy adults before and immediately after erythromycin therapy. All subjects received a five-day course of oral aminophylline 3 mg/kg every six hours prior to and during a five-day course of oral erythromycin stearate (1 g daily). Each subject acted as his own control. Multiple serum samples were collected over ten hours following t...

Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma. The clinical value of the measurements was assessed. Measurement using high-pressure liquid chromatography is simple and requires only a small volume of bloo...

Beta-adrenergic stimulation and alpha 2-adrenergic inhibition increase lipolysis from fat cells. Twenty-eight obese women were placed on a calorie-restricted diet and one of five treatments was applied to one thigh three to five times per week for four weeks: (1) isoproterenol injections; (2) cream containing colforsin (forskolin), aminophylline, and yohimbine; (3) yohimbine cream; (4) colforsi...

A double-blind test to compare IV aminophylline with salbutamol in the treatment of acute, uncontrolled asthma showed that both drugs were equally effective during the first 24 hours. Salbutamol caused a relative tachycardia. Hydrocortisone was given after 2 hours, but did not appear to affect the rate of recovery.