Nitrosation reactions of amino acids with an -NH(2) group [namely, six alpha-amino acids (glycine, alanine, alpha-aminobutyric acid, alpha-aminoisobutyric acid, valine, and norvaline); two beta-amino acids (beta-alanine and beta-aminobutyric acid), and one gamma-amino acid (gamma-aminobutyric acid)] were studied. Nitrosation was carried out in aqueous acid media, mimicking the conditions of the...

microscopy; kainic acid, (KA); lithium-pilocarpine, (LiPC); HS, hippocampal sclerosis; GABA, Gamma-aminobutyric acid; CNS, central nervous system; GER, granuler endoplasmic reticulum= rER, rough endoplasmic reticulum; DNA, deoksiribonucleic acid; RNA, ribonucleic acid; SE, status epilepticus; CA1, cornu ammons 1; CA2, cornu ammons 2; CA3, cornu ammons 3; GD, gyrus dentatus; DGC, dentate granule...

Tryptophan (TRP) is the precursor of melatonin, the primary secretory product of the pineal gland. Hepatic heme deficiency decreases the activity of liver tryptophan pyrrolase, leading to increased plasma TRP and serotonin. As a paradox, patients with attacks of acute intermittent porphyria (AIP), exhibit low nocturnal plasma melatonin levels. This study using a rat experimental model was desig...

Gamma-aminobutyric acid is an important nonprotein amino and has been extensively applied in pharmaceuticals, livestock, food additives, so on. It to develop Corynebacterium glutamicum strains that can efficiently produce gamma-aminobutyric from glucose. In this study, production of C. CGY700 was improved by construction CO2 anaplerotic reaction overexpression citrate synthase. The co-expressio...

Objective(s) Diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of e...