نتایج جستجو برای: amidines

تعداد نتایج: 390  

2011
Thomas D. Getman Rudy L. Luck Caitlin Cienkus

The title compound, 2-B(10)H(9)NH=C(CH(3))N(CH(3))CH(2)CH(2)CH(2)N(CH(3))(2)H·2C(2)H(6)OS or C(8)H(29)B(10)N(3)·2C(2)H(6)OS, is zwitterionic with the negative charge localized on the deca-borate cage and the positive charge on the terminal ammonium group. Two mol-ecules of dimethyl sulfoxide (DMSO) and one mol-ecule of the title compound constitute the asymmetric unit. One DMSO mol-ecule is dis...

2009
Mihaela Cibian Janaina G. Ferreira Garry S. Hanan

The title compound, C(13)H(11)BrN(2)O, a hydroxy-amidine derivative (an amidoxime), was obtained by addition of the corresponding imidoyl chloride to hydroxy-lamine. The benzene and phenyl rings are twisted from the mean plane of the hydroxy-amidine group by 34.4 (1) and 59.2 (1)°, respectively. In the crystal structure, inter-molecular O-H⋯N hydrogen bonds link pairs of mol-ecules, forming cen...

Journal: :The Journal of antibiotics 2001
D Barrett A Tanaka E Watabe K Maki F Ikeda

moiety of 1.8) We have also reported novel methodology for the synthesis of the amide analog of 19) and non-ornithinecontaining macrocyclic lactones.10) Herein, we describe the synthesis and evaluation of a newseries of amidine analogs of the ornithine moiety of FR901469, and the discovery of pyrazolium derivative 8 with reduced hemolytic activity and comparable efficacy to 1 in a murine model ...

Journal: :The Journal of organic chemistry 2010
Rainer Glaser Jian Yin Stephanie Miller

The uncatalyzed, thermal N-inversion reactions were studied of pyrimidin-4(3H)-imine (PMI), pyridin-2(1H)-imine (PYI), and 1H-purine-6(9H)-imine (PUI). Relevant regions of the potential energy surfaces were explored with second-order Moller-Plesset perturbation theory (MP2(full)/6-31G(d)) and with coupled cluster theory (CCSD/6-31G(d), CCSD/6-31+G(d)). The thermochemistry of stationary structur...

2015
Ellen Priscilla Nunes Gadelha Sinésio Talhari Jorge Augusto de Oliveira Guerra Leandro Ourives Neves Carolina Talhari Bernardo Gontijo Roberto Moreira da Silva Junior Anette Chrusciak Talhari

BACKGROUND There have been few studies on pentamidine in the Americas; and there is no consensus regarding the dose that should be applied. OBJECTIVES To evaluate the use of pentamidine in a single dose to treat cutaneous leishmaniasis. METHODS Clinical trial of phase II pilot study with 20 patients. Pentamidine was used at a dose of 7 mg/kg, in a single dose. Safety and adverse effects wer...

Journal: :Journal of medicinal chemistry 2007
Nahoum G Anthony David Breen Joanna Clarke Gavin Donoghue Allan J Drummond Elizabeth M Ellis Curtis G Gemmell Jean-Jacques Helesbeux Iain S Hunter Abedawn I Khalaf Simon P Mackay John A Parkinson Colin J Suckling Roger D Waigh

The synthesis and properties of 80 short minor groove binders related to distamycin and the thiazotropsins are described. The design of the compounds was principally predicated upon increased affinity arising from hydrophobic interactions between minor groove binders and DNA. The introduction of hydrophobic aromatic head groups, including quinolyl and benzoyl derivatives, and of alkenes as link...

2015
Wataru Makiguchi Junki Tanabe Hidekazu Yamada Hiroki Iida Daisuke Taura Naoki Ousaka Eiji Yashima

Self-recognition and self-discrimination within complex mixtures are of fundamental importance in biological systems, which entirely rely on the preprogrammed monomer sequences and homochirality of biological macromolecules. Here we report artificial chirality- and sequence-selective successive self-sorting of chiral dimeric strands bearing carboxylic acid or amidine groups joined by chiral ami...

Journal: :Journal of the American Chemical Society 2016
Kazuya Douki Hiroyuki Ono Tohru Taniguchi Jun Shimokawa Masato Kitamura Tohru Fukuyama

Optically pure hinckdentine A was synthesized on a 300 mg scale via an asymmetric catalysis-based strategy. The key steps to the first asymmetric synthesis involved (i) enantioselective dearomative cyclization of an achiral N-acyl indole that allowed for the efficient construction of the key polycyclic indoline intermediate with a crucial tetrasubstituted stereogenic carbon center, (ii) Beckman...

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