BACKGROUND Granular cell ameloblastoma is a rare histological subtype of ameloblastoma accounting for less than 5% of the total. The characteristic microscopic features of granular cells are attributed to the increased presence of lysosomes in the cytoplasm of the tumour cells. METHODS A case of bone expansion in the mandible of 65 year old patient was examined on the basis of the clinical ex...

BACKGROUND Ameloblastoma is a rare benign odontogenic tumor with locally aggressive behavior and a high recurrence rate. When metastases occur, which are uncommon, lungs constitute the most frequent site involved. Malignant ameloblastomas are different from ameloblastic carcinomas. Malignant ameloblastomas are tumors considered metastatic despite the appearance of well-differentiated or benign ...

UNLABELLED Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase. This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma. MATERIAL AND METHODS Using the World Health Organization (WHO) criteria fo...

UNLABELLED Statement of the Problem : Ameloblastoma is the most common odontogenic tumor which is slow-growing, locally invasive and exhibit specific biologic behavior and high recurrence rate. Likewise, odontogenic keratocyst is a developmental odontogenic cyst that has a high recurrence rate and aggressive behavior. There are limited studies considering the relationship between the angiogenes...

Unicystic ameloblastoma is a tumor of odontogenic origin. It is not a rare neoplasm and most often the lesion is asympthomatic. However, large lesions may cause painless swelling of the jaws. Here we report a case of unicystic ameloblastoma with pain, swelling of the posterior jaws along with teeth mobility. Samples of incisional biopsy of the lesion and also interaoperative frozen section were...

BACKGROUND Canonical and non-canonical Wnt signaling pathways modulate diverse cellular processes during embryogenesis and post-natally. Their deregulations have been implicated in cancer development and progression. Wnt signaling is essential for odontogenesis. The ameloblastoma is an odontogenic epithelial neoplasm of enamel organ origin. Altered expressions of Wnts-1, -2, -5a, and -10a are d...

A 23-year-old Malay female patient presented with a history of pain and swelling over right maxilla. Imaging showed well-defined unilocular radiolucency areas radiopacity in the The lesion was initially thought to be unicystic ameloblastoma. However, histopathology excised proved otherwise final diagnosis given as dentinogenic ghost cell tumour. clinical presentation case, subtypes DGCT, simila...

AIM OF THE STUDY To investigate the expression status and association of β-catenin and AXIN2 in ameloblastoma. MATERIAL AND METHODS 30 ameloblastoma specimens and 10 normal oral mucosa tissues were enrolled in the study. The protein and RNA levels of β-catenin and AXIN2 were detected by immunohistochemistry staining, Western blot, and real-time PCR analysis. The relationship between β-catenin...

Although ameloblastoma and adenomatoid odontogenic tumor (AOT) belong to the same group according to the World Health Organization, they show different biologic behaviors. PCNA, an amplifier of cell proliferation, and p53, a tumor suppressor protein, are overexpressed in some odontogenic lesions. The purpose of this study was to immunohistochemically evaluate the expression of p53 and PCNA to c...

Odontogenic tumors comprise a diverse group of lesions with varied clinical behaviour and histological patterns. Although ameloblastoma is the most common odontogenic tumor, it is a relatively rare tumor occurring in the jaws, representing only around one percent of oral tumours. It is a benign but locally invasive tumor and is more common in the mandible. These tumors usually present as slow g...