نتایج جستجو برای: amacr
تعداد نتایج: 195 فیلتر نتایج به سال:
Tubulocystic renal cell carcinoma (TCRCC) is a rare, recently characterized RCC subtype with distinctive clinicopathologic and genetic characterizations as well as typical behaviors in an indolent fashion. However, sporadic case reports in the literature have indicated that TCRCC with sarcomatoid differentiation or poorly differentiated (PD) foci could behave aggressively. Herein, we reported t...
BACKGROUND Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups derived from integrated genomics linked with clinical outcome. METHODS In a study of 482 tumour, benign and germline samples from 259 men with primary prostate cancer, we used ...
Introduction: Prostate cancer is a multifaceted disease comprises distinct biological subtypes with varied spectrum of clinical, pathologic and molecular features with different prognostic and therapeutic implications. Over the last few decades there have been outstanding advances in prostate cancer management leading to earlier detection of disease. Prostatic cancer diagnosis is based on a com...
A 49-year-old woman underwent computed tomography (CT) examination of the chest and abdomen following a road traffic accident. This revealed bilateral solid renal masses. A subsequent CT examination with intravenous contrast demonstrated one solid enhancing lesion of 26 mm in the upper pole of the right kidney and two solid enhancing lesions of 27 mm each in the left kidney, one of which extend...
Anti-1-amino-3-[(18)F] fluorocyclobutane-1-carboxylic acid (anti-3-[(18)F] FACBC) is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma. The aim of this study is to correlate uptake of anti-3-[(18)F] FACBC with histology of prostatectomy specimens in patients undergoing radical prostatectomy and to determine if upt...
lack of prostate specificity and intercellular localiza-tion of its gene product make this gene a poor serum biomarker. FN1 (fibronectin 1) and VEGF (vascular endo-thelial growth factor) are associated with prostate cancer and encode secreted proteins; however, these genes lack prostate-specific tissue specificity (15–18). The lack of prostate tissue specificity in the expression of these 2 gen...
Phytanic acid is a saturated branched-chain fatty acid found predominantly in red meat and dairy products, and may contribute to the elevated risks of prostate cancer associated with higher consumption of these foods. Pristanic acid is formed during peroxisomal oxidation of phytanic acid, and is the direct substrate of α-Methyl-CoA-Racemase (AMACR)--an enzyme that is consistently overexpressed ...
INTRODUCTION Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth. Metformin is known for its anti-cancer effect. Here, we examined the anti-cancer effect of Exendin-4 and metformin using a prostate cancer model. METHODS Prostate cancer ...
BACKGROUND Prostate cancer involving the rectal wall is rare and may lead to diagnostic pitfalls. CASE PRESENTATION Out of 9504 patients with rectal tumors between January 2003 and January 2015, 9 patients (elderly with a mean age of 74 years) with prostate cancer involving the rectal wall were clinically misdiagnosed with rectal cancer. The lesions were located in the rectum, and included 3 ...
OBJECTIVE To study the clinicopathological features, differential diagnosis and prognosis of clear cell papillary renal cell carcinoma (CCPRCC). METHODS The histological, immunohistochemical, and molecular features were studied in 11 cases and follow-up data were also analyzed. RESULTS There were a total of 3 females and 8 males. The age of patients were ranged from 33 to 72 years(mean age ...
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