224 words Introduction: 597 words Discussion: 1331 words ABBREVIATIONS: AM251, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1Hpyrazole-3-carboxamide; CHX, cycloheximide; ERR, estrogen-related receptor; ERRE, ERR-responsive element; PGC-1, peroxisome proliferator-activated receptor γ coactivator-1; PMA, phorbol 12-myristate 13-acetate; rimonabant (SR141716A), 5-(4-chloropheny...

objective(s) the mechanism(s) by which antidepressants regulate the hypothalamic-pituitary-adrenal (hpa) axis remain elusive. the endocannabinoid system (ecbs) which exhibits antidepressant potential, appears to regulate the hpa axis activity. therefore, we aimed to investigate the role of the ecbs in the action of doxepin including its effect on the hpa axis. materials and methods male wistar ...

Although the activation of cannabinoid receptor-1 (CB1) receptors by cannabinoids is known to inhibit neuronal hyperexcitability and reduce excitotoxic cell death, the mechanistic links between these two actions remain elusive. We tested the hypothesis that activation of CB1 receptors inhibits N-methyl-d-aspartic acid (NMDA)-mediated calcium influx and cell death via the inositol triphosphate (...

Background and Purpose: Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory. The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1R) and cannabinoi...

BACKGROUND AND PURPOSE The effects of centrally administered cannabinoids on body core temperature (Tc) and the contribution of endogenous cannabinoids to thermoregulation and fever induced by lipopolysaccharide (LPS) (Sigma Chem. Co., St. Louis, MO, USA) were investigated. EXPERIMENTAL APPROACH Drug-induced changes in Tc of male Wistar rats were recorded over 6 h using a thermistor probe (Ye...