introduction: to study the effect of gallic acid (ga) on hippocampal long-term potentiation (ltp) and histological changes in animal model of alzheimer disease (ad) induced by betaamyloid (aβ). methods: sixty-four adult male wistar rats (300±20 g) were divided into 8 groups: 1) control (cont); 2) ad; 3) sham; 4-7) ad+ga (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) cont+ga100, aβ ...

alzheimer's disease (ad), a common and debilitating neurodegenerative disorder, affect more than 65 million individuals throughout the world. this disability plays a crucial role in daily activities such as driving. several studies have investigated the relationship between cognitive functions and driving safety. the current study revises the literature on the relation between road safety ...

alzheimer's disease (ad) is considered as the greatest thread to adults aged 65 and older. it stands as the most common cause of dementia, the prevalence of which is around 24 million worldwide. ad is a progressive and degenerative disorder that combats the neurons, leading to impairment of different cognitive functions. ad is characterized by an accumulation of two factors normally presen...

metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. in cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (nafld) and non-alcoholic steatotic hepatitis (nash) the  liver  does not function thoroughly due to long-term damage. unfortunately the early detection of cirrhosis, hcc, na...

background: alzheimer’s disease was known as a progressive neurodegenerative disorder in the elderly and is characterized by dementia and severe neuronal loss in the some regions of brain such as nucleus basalis magnocellularis. it plays an important role in the brain functions such as learning and memory. loss of cholinergic neurons of nucleus basalis magnocellularis by ibotenic acid can commo...

parkinson`s disease (pd) is the second most common neurodegenerative disorder after alzheimer`s disease. it is a chronic and progressive disease, and mostly afflicts elderlies. pd starts with sudden onsets and the exact cause of the disease is still unknown, however there are some early symptoms that can help us to diagnose the disease and ameliorate its effects. pd is a multi-factorial disease...