Tibetans are well adapted to living and thriving in high-altitude environments. Mitochondria are central links to oxygen consumption, and variations in mitochondrial DNA (mtDNA) could play a role in high-altitude adaptation. Alleles at several polymorphic sites in mtDNA define common haplotypes, or haplogroups, including some that have been implicated in the risk of developing certain diseases....

A relation exists between high altitude exposure and a hypercoagulable state, the nature of which is not entirely clear. This has been mostly reported in mountain climbers. We report a 19-yr-old female, working as a high-altitude chamber instructor, who presented with severe frontal headaches which persisted for a month following routine high altitude chamber training. The patient was in genera...

This study was undertaken to investigate the mechanisms of effects of high altitude on spontaneous and irradiationinduced neoplasia, with particular reference to the influence of the time and duration of high-altitude exposure on the pathogenesis of such growths. Female RF/Un mice exposed to 150 R whole-body Xor sham irradiation at 10 weeks of age were subsequently housed at high (4540 m) or lo...

Denis Jourdanet (1815-1892) was a French physician who spent many years in Mexico studying the effects of high altitude. He was a major benefactor of Paul Bert (1833-1886), who is often called the father of high-altitude physiology because his book La pression barométrique was the first clear statement that the harmful effects of high altitude are caused by the low partial pressure of oxygen. H...

People who visit high-altitude areas are exposed to a stressful environment and a good percentage of them suffer from high-altitude-induced diseases, including systemic hypertension. Identification of genetic markers for high-altitude-induced diseases would help to reduce the rate of morbidity/mortality from such diseases. The development of systemic hypertension on exposure to high altitude (3...

This document is disseminated under the sponsorship of the Department of Transportation, Federal Aviation Administration, in the interest of information exchange. The United States Government assumes no liability for its contents or use thereof. Thunderstorms are a leading cause of delay in the National Airspace System (NAS), and significant research has been conducted to predict the areas pilo...

Phyllostachys pubescens forests play an important role in soil organic carbon (SOC) sequestration in terrestrial ecosystems. However, the estimation and mechanism of SOC sequestration by P. pubescens forests remain unclear. In this study, the effect of P. pubescens forest distribution with elevation was investigated at two altitude sites in Jian-ou City, Southeast China. SOC storage was estimat...

Pulmonary arterial hypertension in man at altitude was first demonstrated by Rotta, Canepa. Hurtado. Velasquez & Chavez (1956). One year before Vega (1955) had published the first comprehensive clinical account of high altitude pulmonary oedema. Since the mid-sixties. interest in both pulmonary hypertension and pulmonary oedema at altitude has continued to generate a great deal of clinical and ...

BACKGROUND People suffer unique health problems in high altitude areas, due to such factors as elevation, aircraft ascent and descent, extreme cold, hypoxia, hypobaria, and low relative humidity. This study was conducted to evaluate ENT morbidity at high altitude. METHODS Serving soldiers introduced to a high altitude environment who presented with various ENT symptoms were examined to identi...

High altitude acclimatization and adaptation mechanisms have been well clarified, however, high altitude de-adaptation mechanism remains unclear. In this study, we conducted a controlled study on cardiac functions in 96 healthy young male who rapidly entered the high altitude (3700 m) and returned to the plains (1500 m) after 50 days. Ninety eight healthy male who remained at low altitude were ...