A surgical needle will generally not penetrate an endotracheal tube (ETT) and intraoperative ETT cuff perforation is uncommon because the cuff, which is the weakest part of the tube, is placed in the subglottic trachea. We report a very rare case, in which an intraoperative airway air leak during maxillary advancement surgery was postoperatively confirmed to be due to ETT cuff deflation because...

Esters of phthalates, mainly applied as plasticizer, cause several human health and environment    hazards. Phthalates are widely used in pharmaceutical products, cosmetics, as well as other plastic commercial products, and can penetrate in foods, water dusts, and air leading to ingestion and inhalation exposure followed by skin absorption for human. These compounds cause serious adverse effect...

Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica cochinchinensis trypsin inhibitor II (MCoTI-II). M...

Correspondence to: Sadik Esener, [email protected]; Joseph Wang, [email protected]. †These authors contributed equally to this work. Supporting information for this article is available on the WWW under http://www.angewandte.org or from the author. NIH Public Access Author Manuscript Angew Chem Int Ed Engl. Author manuscript; available in PMC 2013 July 23. Published in final edited form as: An...

Nanosecond electric pulses generate nanopores in the interior membranes of cells and modulate cellular functions. Here, we used confocal microscopy and flow cytometry to observe Smith antigen antibody (Y12) binding to nuclear speckles, known as small nuclear ribonucleoprotein particles (snRNPs) or intrachromatin granule clusters (IGCs), in Jurkat cells following one or five 10ns, 150kV/cm pulse...

Recommending online news articles has become a promising research direction as the Internet provides fast access to real-time information from multiple sources around the world. Many online readers have their own reading preference on news articles; however, a group of users might be interested in similar fascinating topics. It would be helpful to take into consideration the individual and grou...

Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. No synthetic drug delivery system composed of biodegradable polymers has been shown to penetrate highly viscoelastic human mucus, such as...

Bacteria communicate with each other by the use of signaling molecules, a process called 'quorum sensing'. One group of quorum sensing molecules includes the oligopeptides, which are mainly produced by Gram-positive bacteria. Recently, these quorum sensing peptides were found to biologically influence mammalian cells, promoting i.a. metastasis of cancer cells. Moreover, it was found that bacter...

Furthermore, by using [2, p. 230, (1)] a computable representation for the G-function in (1) (and hence also for F,112(s)) may be given in terms of essentially a linear combination of four hypergeometric functions OF3[b2s2 /16] provided that no two of the parameters {1, 1 1+v-P1v-P) differ by an integer. This result for Fv-112(s) is given (correctly) in [3, p. 353, (9)] so that the proposed int...

Candida albicans must penetrate the endothelial cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infection. We compared 27 C. albicans mutants with their wild-type parent for their capacity to damage endothelial cells in vitro and cause a lethal infection in mice following tail vein inoculation. Of 10 mutants with significantly impaired capacity to ...