Statistical shape analysis has become of increasing interest to the neuroimaging community due to its potential to precisely locate morphological changes and thus potentially discriminate between healthy and pathological structures. This paper describes a combined boundary and medial shape analysis based on two different shape descriptions applied to a study of the hippocampus shape abnormaliti...

An improvement of the Active Shape procedure introduced by Cootes and Taylor is presented. The new automated brain segmenta-tion and interpretation approach incorporates a priori knowledge about neuroanatomic structures and their speciic structural relationships to provide robust segmentation and labeling. The method was trained in 8 MR brain images and tested in 19 brain images by comparison t...

The generative surface reconstruction problem can be stated like this: Given a finite collection of 3D shapes, create a small set of functions that can be combined to generate the given shapes procedurally. We propose generative fact labeling (GFL) as an attempt to organize the iterative process of shape analysis and shape synthesis in a systematic way. We present our results for the reconstruc...

We present the first determination of the strong coupling constant from the three-jet rate in e{+}e{-} annihilation at LEP, based on a next-to-next-to-leading-order (NNLO) perturbative QCD prediction. More precisely, we extract alpha{s}(M{Z}) by fitting perturbative QCD predictions at O(alpha{s}{3}) to data from the ALEPH experiment at LEP. Over a large range of the jet-resolution parameter y{c...

alpha-Dystroglycan has been isolated from chicken cardiac muscle and its molecular weight was estimated to be approximately 135 kDa. The avian protein interacts with murine Engelbreth-Holm-Swarm (EHS) tumor laminin via interaction with the C-terminal LG4 and LG5 domains (fragment E3) of the laminin alpha-chain. This laminin binding is calcium-dependent and can be competed by heparin. Electron m...

High-resolution radar images reveal near-Earth asteroid (66391) 1999 KW4 to be a binary system. The approximately 1.5-kilometer-diameter primary (Alpha) is an unconsolidated gravitational aggregate with a spin period approximately 2.8 hours, bulk density approximately 2 grams per cubic centimeter, porosity approximately 50%, and an oblate shape dominated by an equatorial ridge at the object's p...

This article is concerned with a spectral optimization problem: in smooth bounded domain $${\Omega }$$ , for function m and nonnegative parameter $$\alpha $$ consider the first eigenvalue $$\lambda _\alpha (m)$$ of operator $${\mathcal {L}}_m$$ given by {L}}_m(u)= -{\text {div}} \left( 1+\alpha m)\nabla u\right) -mu$$ . Assuming uniform pointwise integral bounds on m, we investigate issue minim...

Under substrate adherent conditions, integrin gene expression can be regulated by transforming growth factor-beta, interleukin-1 beta, and prostaglandins. This report demonstrates a new mechanism that can differentially control the expression of several integrins. When MG-63 osteosarcoma cells are maintained in suspension, up-regulation of several integrin alpha-subunits takes place. Within as ...

Substitution rates at the three codon positions (r1, r2, and r3) of mammalian mitochondrial genes are in the order of r3 > r1 > r2, and the rate heterogeneity at the three positions, as measured by the shape parameter of the gamma distribution (alpha 1, alpha 2, and alpha 3), is in the order of alpha 3 > alpha 1 > alpha 2. The causes for the rate heterogeneity at the three codon positions remai...