The early results of revision osteoarticular allografts in weight-bearing joints are reported. Sixteen consecutive patients underwent surgery over a six-year period between 1982 and 1988. At the time of review eight patients (50%) had surviving second allografts with an average follow-up time of 48 months (range 12 to 87). Five patients were graded excellent according to the Mankin scale, one g...

NINETEEN liver and 51 kidney retrievals (one pediatric pair is considered as a smgle organ) were performed in 26 non-heart-beating donors (NHBD) over a 5.5-year period. Consent for liver procurement was not obtained in seven cases. Fifty-seven allografts (14 livers and 43 kidneys) were transplanted while the remainder (5 livers and 8 kidneys) were discarded because of macroscopic and/or microsc...

the preventive effect of NKT-01on the rejection of renal allografts in dogs, and suggested that NKT-01 maybe useful in clinical organ transplantation.70 In this study we have explored the efficacy of NKT-01 in treating acute rejection episodes in dogs receiving renal allografts. Unrelated outbred beagle dogs were used for the experiment. Renal allografting was performed as previously described....

the present review classifies and describes the multifactorial causes of anterior cruciate ligament (acl) surgery failure, concentrating on preventing and resolving such situations. the article particularly focuses on those causes that require acl revision due to recurrent instability, without neglecting those that affect function or produce persistent pain. although primary acl reconstruction ...

Successful allogeneic hematopoietic stem cell transplantation (HSCT) requires reconstitution of normal T-cell immunity. Recipient thymic activity, biologic features of the allograft, and preparative regimens all contribute to immune reconstitution. We evaluated circulating T-cell phenotypes and T-cell receptor rearrangement excision circles (TRECs) in 331 blood samples from 158 patients who had...

Despite the use of immunosuppressive drugs, chronic allograft rejection remains a major hurdle in transplantation medicine. Induction of specific immunologic tolerance to antigens expressed by the graft would avoid its eventual functional loss and the severe side effects of paralyzing the immune system. We previously showed that donor-specific regulatory T-lymphocytes prevent rejection of fully...

In cardiac transplantation, chronic rejection takes the form of an occlusive vasculopathy. The mechanism underlying this disorder remains unclear. The purpose of this study was to investigate the role nitric oxide (NO) may play in the development of allograft arteriosclerosis. Rat aortic allografts from ACI donors to Wistar Furth recipients with a strong genetic disparity in both major and mino...